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Attenuated cold sensitivity in TRPM8 null mice.
Neuron. 2007 May 03; 54(3):379-86.N

Abstract

Thermosensation is an essential sensory function that is subserved by a variety of transducer molecules, including those from the Transient Receptor Potential (TRP) ion channel superfamily. One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro. However, its roles in cold thermosensation and pain in vivo have not been fully elucidated. Here, we show that sensory neurons derived from TRPM8 null mice lack detectable levels of TRPM8 mRNA and protein and that the number of these neurons responding to cold (18 degrees C) and menthol (100 microM) is greatly decreased. Furthermore, compared with WT mice, TRPM8 null mice display deficiencies in certain behaviors, including icilin-induced jumping and cold sensation, as well as a significant reduction in injury-induced responsiveness to acetone cooling. These results suggest that TRPM8 may play an important role in certain types of cold-induced pain in humans.

Authors+Show Affiliations

Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, L.L.C., Spring House, PA 19477-0776, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17481392

Citation

Colburn, Raymond W., et al. "Attenuated Cold Sensitivity in TRPM8 Null Mice." Neuron, vol. 54, no. 3, 2007, pp. 379-86.
Colburn RW, Lubin ML, Stone DJ, et al. Attenuated cold sensitivity in TRPM8 null mice. Neuron. 2007;54(3):379-86.
Colburn, R. W., Lubin, M. L., Stone, D. J., Wang, Y., Lawrence, D., D'Andrea, M. R., Brandt, M. R., Liu, Y., Flores, C. M., & Qin, N. (2007). Attenuated cold sensitivity in TRPM8 null mice. Neuron, 54(3), 379-86.
Colburn RW, et al. Attenuated Cold Sensitivity in TRPM8 Null Mice. Neuron. 2007 May 3;54(3):379-86. PubMed PMID: 17481392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuated cold sensitivity in TRPM8 null mice. AU - Colburn,Raymond W, AU - Lubin,Mary Lou, AU - Stone,Dennis J,Jr AU - Wang,Yan, AU - Lawrence,Danielle, AU - D'Andrea,Michael R, AU - Brandt,Michael R, AU - Liu,Yi, AU - Flores,Christopher M, AU - Qin,Ning, PY - 2006/08/31/received PY - 2006/12/26/revised PY - 2007/03/14/accepted PY - 2007/5/8/pubmed PY - 2007/6/22/medline PY - 2007/5/8/entrez SP - 379 EP - 86 JF - Neuron JO - Neuron VL - 54 IS - 3 N2 - Thermosensation is an essential sensory function that is subserved by a variety of transducer molecules, including those from the Transient Receptor Potential (TRP) ion channel superfamily. One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro. However, its roles in cold thermosensation and pain in vivo have not been fully elucidated. Here, we show that sensory neurons derived from TRPM8 null mice lack detectable levels of TRPM8 mRNA and protein and that the number of these neurons responding to cold (18 degrees C) and menthol (100 microM) is greatly decreased. Furthermore, compared with WT mice, TRPM8 null mice display deficiencies in certain behaviors, including icilin-induced jumping and cold sensation, as well as a significant reduction in injury-induced responsiveness to acetone cooling. These results suggest that TRPM8 may play an important role in certain types of cold-induced pain in humans. SN - 0896-6273 UR - https://www.unboundmedicine.com/medline/citation/17481392/Attenuated_cold_sensitivity_in_TRPM8_null_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(07)00296-6 DB - PRIME DP - Unbound Medicine ER -