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Brain serotonin depletion impairs short-term memory, but not long-term memory in rats.
Physiol Behav. 2007 Aug 15; 91(5):652-7.PB

Abstract

Intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) (150 microg; 4.5 microl/ventricle), a serotonergic neurotoxin, significantly decreased spontaneous alternation in Y-maze task and working memory in radial 8 arm-maze task, suggesting effects on short-term memory, without affecting long-term memory, explored by reference memory in radial 8 arm-maze task and step-through latency in multi-trial passive avoidance task. Parachlorophenylalanine (PCPA) (3 days treatment 200 microg, i.c.v.), a serotonin synthesis inhibitor, did not impair step-through-latency in multi-trial passive avoidance task, suggesting no effects on long-term memory. These results suggest that serotonin, among other neurotransmitters, play an important role in cognitive functions, especially short-term memory.

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Authors+Show Affiliations

Hritcu L
Alexandru Ioan Cuza University, Department of Physiology, Blv Carol I no 20A, 700506, Iasi, Romania. hritcu@uaic.ro
Clicinschi M
No affiliation info available
Nabeshima T
No affiliation info available

MeSH

5,7-DihydroxytryptamineAnimalsAvoidance LearningBrainFenclonineInjections, IntraventricularMaleMaze LearningMemory, Short-TermRatsRats, WistarRetention, PsychologySerotoninSerotonin Agents

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17481676

Citation

Hritcu, Lucian, et al. "Brain Serotonin Depletion Impairs Short-term Memory, but Not Long-term Memory in Rats." Physiology & Behavior, vol. 91, no. 5, 2007, pp. 652-7.
Hritcu L, Clicinschi M, Nabeshima T. Brain serotonin depletion impairs short-term memory, but not long-term memory in rats. Physiol Behav. 2007;91(5):652-7.
Hritcu, L., Clicinschi, M., & Nabeshima, T. (2007). Brain serotonin depletion impairs short-term memory, but not long-term memory in rats. Physiology & Behavior, 91(5), 652-7.
Hritcu L, Clicinschi M, Nabeshima T. Brain Serotonin Depletion Impairs Short-term Memory, but Not Long-term Memory in Rats. Physiol Behav. 2007 Aug 15;91(5):652-7. PubMed PMID: 17481676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain serotonin depletion impairs short-term memory, but not long-term memory in rats. AU - Hritcu,Lucian, AU - Clicinschi,Monica, AU - Nabeshima,Toshitaka, Y1 - 2007/04/01/ PY - 2006/11/20/received PY - 2007/03/23/revised PY - 2007/03/27/accepted PY - 2007/5/8/pubmed PY - 2007/12/6/medline PY - 2007/5/8/entrez SP - 652 EP - 7 JF - Physiology & behavior JO - Physiol Behav VL - 91 IS - 5 N2 - Intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) (150 microg; 4.5 microl/ventricle), a serotonergic neurotoxin, significantly decreased spontaneous alternation in Y-maze task and working memory in radial 8 arm-maze task, suggesting effects on short-term memory, without affecting long-term memory, explored by reference memory in radial 8 arm-maze task and step-through latency in multi-trial passive avoidance task. Parachlorophenylalanine (PCPA) (3 days treatment 200 microg, i.c.v.), a serotonin synthesis inhibitor, did not impair step-through-latency in multi-trial passive avoidance task, suggesting no effects on long-term memory. These results suggest that serotonin, among other neurotransmitters, play an important role in cognitive functions, especially short-term memory. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/17481676/Brain_serotonin_depletion_impairs_short_term_memory_but_not_long_term_memory_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(07)00121-7 DB - PRIME DP - Unbound Medicine ER -