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Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.
Curr Biol. 2007 May 15; 17(10):873-80.CB

Abstract

Neurons that produce dopamine as a neurotransmitter constitute a heterogeneous group involved in the control of various behaviors and physiology. In mammals, dopaminergic neurons are found in distinct clusters mainly located in the ventral midbrain and the caudal forebrain [1]. Although much is known about midbrain dopaminergic neurons, development of diencephalic dopaminergic neurons is poorly understood. Here we demonstrate that Orthopedia (Otp) homeodomain protein is essential for the development of specific subsets of diencephalic dopaminergic neurons. Zebrafish embryos lacking Otp activity are devoid of dopaminergic neurons in the hypothalamus and the posterior tuberculum. Similarly, Otp-/- mouse [2, 3] embryos lack diencephalic dopaminergic neurons of the A11 group, which constitutes the diencephalospinal dopaminergic system. In both systems, Otp is expressed in the affected dopaminergic neurons as well as in potential precursor populations, and it might contribute to dopaminergic cell specification and differentiation. In fish, overexpression of Otp can induce ectopic tyrosine hydroxylase and dopamine transporter expression, indicating that Otp can specify aspects of dopaminergic identity. Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system.

Authors+Show Affiliations

Department of Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17481897

Citation

Ryu, Soojin, et al. "Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development." Current Biology : CB, vol. 17, no. 10, 2007, pp. 873-80.
Ryu S, Mahler J, Acampora D, et al. Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Curr Biol. 2007;17(10):873-80.
Ryu, S., Mahler, J., Acampora, D., Holzschuh, J., Erhardt, S., Omodei, D., Simeone, A., & Driever, W. (2007). Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Current Biology : CB, 17(10), 873-80.
Ryu S, et al. Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development. Curr Biol. 2007 May 15;17(10):873-80. PubMed PMID: 17481897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. AU - Ryu,Soojin, AU - Mahler,Julia, AU - Acampora,Dario, AU - Holzschuh,Jochen, AU - Erhardt,Simone, AU - Omodei,Daniela, AU - Simeone,Antonio, AU - Driever,Wolfgang, Y1 - 2007/05/03/ PY - 2006/11/29/received PY - 2007/03/30/revised PY - 2007/04/02/accepted PY - 2007/5/8/pubmed PY - 2007/8/19/medline PY - 2007/5/8/entrez SP - 873 EP - 80 JF - Current biology : CB JO - Curr. Biol. VL - 17 IS - 10 N2 - Neurons that produce dopamine as a neurotransmitter constitute a heterogeneous group involved in the control of various behaviors and physiology. In mammals, dopaminergic neurons are found in distinct clusters mainly located in the ventral midbrain and the caudal forebrain [1]. Although much is known about midbrain dopaminergic neurons, development of diencephalic dopaminergic neurons is poorly understood. Here we demonstrate that Orthopedia (Otp) homeodomain protein is essential for the development of specific subsets of diencephalic dopaminergic neurons. Zebrafish embryos lacking Otp activity are devoid of dopaminergic neurons in the hypothalamus and the posterior tuberculum. Similarly, Otp-/- mouse [2, 3] embryos lack diencephalic dopaminergic neurons of the A11 group, which constitutes the diencephalospinal dopaminergic system. In both systems, Otp is expressed in the affected dopaminergic neurons as well as in potential precursor populations, and it might contribute to dopaminergic cell specification and differentiation. In fish, overexpression of Otp can induce ectopic tyrosine hydroxylase and dopamine transporter expression, indicating that Otp can specify aspects of dopaminergic identity. Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system. SN - 0960-9822 UR - https://www.unboundmedicine.com/medline/citation/17481897/Orthopedia_homeodomain_protein_is_essential_for_diencephalic_dopaminergic_neuron_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(07)01209-2 DB - PRIME DP - Unbound Medicine ER -