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Hippocampal size and dementia in stroke patients: the Sydney stroke study.
J Neurol Sci 2007; 260(1-2):71-7JN

Abstract

BACKGROUND

Hippocampal atrophy is an early feature of Alzheimer's disease (AD) but it has also been reported in vascular dementia (VaD). It is uncertain whether hippocampal size can help differentiate the two disorders.

METHODS

We assessed 90 stroke/TIA patients 3-6 months after the event, and 75 control subjects, with neuropsychological tests, medical and psychiatric examination and brain MRI scans. A diagnosis of VaD, vascular mild cognitive impairment (VaMCI) or no cognitive impairment (NCI) was reached by consensus on agreed criteria. T1-weighted MRI was used to obtain total intracranial volume (TICV), gray and white matter volume, CSF volume, hippocampus and amygdala volumes, and T2-weighted scans for white matter hyperintensity (WMH) ratings.

RESULTS

Stroke/TIA patients had more white matter hyperintensities (WMHs), larger ventricle-to-brain ratios and smaller amygdalae than controls, but hippocampus size and gray and white matter volumes were not different. WMHs and amygdala but not hippocampal volume distinguished stroke/TIA patients with VaD and VaMCI and without NCI and amygdala volumes. Right hippocampus volume significantly correlated with new visual learning.

CONCLUSIONS

Stroke/TIA patients and patients with post-stroke VaMCI or mild VaD do not have hippocampal atrophy. The amygdala is smaller in stroke/TIA patients, especially in those with cognitive impairment, and this may be accounted for by white matter lesions. The hippocampus volume relates to episodic memory, especially right hippocampus and new visual learning. A longitudinal study of these subjects will determine whether hippocampal atrophy is a late development in VaD.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, Sydney, Australia; Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia. p.sachdev@unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17482210

Citation

Sachdev, P S., et al. "Hippocampal Size and Dementia in Stroke Patients: the Sydney Stroke Study." Journal of the Neurological Sciences, vol. 260, no. 1-2, 2007, pp. 71-7.
Sachdev PS, Chen X, Joscelyne A, et al. Hippocampal size and dementia in stroke patients: the Sydney stroke study. J Neurol Sci. 2007;260(1-2):71-7.
Sachdev, P. S., Chen, X., Joscelyne, A., Wen, W., Altendorf, A., & Brodaty, H. (2007). Hippocampal size and dementia in stroke patients: the Sydney stroke study. Journal of the Neurological Sciences, 260(1-2), pp. 71-7.
Sachdev PS, et al. Hippocampal Size and Dementia in Stroke Patients: the Sydney Stroke Study. J Neurol Sci. 2007 Sep 15;260(1-2):71-7. PubMed PMID: 17482210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal size and dementia in stroke patients: the Sydney stroke study. AU - Sachdev,P S, AU - Chen,X, AU - Joscelyne,A, AU - Wen,W, AU - Altendorf,A, AU - Brodaty,H, Y1 - 2007/05/04/ PY - 2007/01/24/received PY - 2007/04/03/accepted PY - 2007/5/8/pubmed PY - 2007/12/7/medline PY - 2007/5/8/entrez SP - 71 EP - 7 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 260 IS - 1-2 N2 - BACKGROUND: Hippocampal atrophy is an early feature of Alzheimer's disease (AD) but it has also been reported in vascular dementia (VaD). It is uncertain whether hippocampal size can help differentiate the two disorders. METHODS: We assessed 90 stroke/TIA patients 3-6 months after the event, and 75 control subjects, with neuropsychological tests, medical and psychiatric examination and brain MRI scans. A diagnosis of VaD, vascular mild cognitive impairment (VaMCI) or no cognitive impairment (NCI) was reached by consensus on agreed criteria. T1-weighted MRI was used to obtain total intracranial volume (TICV), gray and white matter volume, CSF volume, hippocampus and amygdala volumes, and T2-weighted scans for white matter hyperintensity (WMH) ratings. RESULTS: Stroke/TIA patients had more white matter hyperintensities (WMHs), larger ventricle-to-brain ratios and smaller amygdalae than controls, but hippocampus size and gray and white matter volumes were not different. WMHs and amygdala but not hippocampal volume distinguished stroke/TIA patients with VaD and VaMCI and without NCI and amygdala volumes. Right hippocampus volume significantly correlated with new visual learning. CONCLUSIONS: Stroke/TIA patients and patients with post-stroke VaMCI or mild VaD do not have hippocampal atrophy. The amygdala is smaller in stroke/TIA patients, especially in those with cognitive impairment, and this may be accounted for by white matter lesions. The hippocampus volume relates to episodic memory, especially right hippocampus and new visual learning. A longitudinal study of these subjects will determine whether hippocampal atrophy is a late development in VaD. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17482210/Hippocampal_size_and_dementia_in_stroke_patients:_the_Sydney_stroke_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00275-4 DB - PRIME DP - Unbound Medicine ER -