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Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations.
Mitochondrion 2007; 7 Suppl:S78-88M

Abstract

Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a dose of 2400 mg using one specific chewable tablet formulation. The efficiency of absorption decreases as the dose increases. About 95% of circulating CoQ10 occurs as ubiquinol, with no appreciable change in the ratio following CoQ10 ingestion. Higher plasma CoQ10 concentrations are necessary to facilitate uptake by peripheral tissues and also the brain. Solubilized formulations of CoQ10 (both ubiquinone and ubiquinol) have superior bioavailability as evidenced by their enhanced plasma CoQ10 responses.

Authors+Show Affiliations

Tishcon Corporation, 30 New York Avenue, P.O. Box 331, Westbury, NY 11590, USA. hemmi@tishcon.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17482886

Citation

Bhagavan, Hemmi N., and Raj K. Chopra. "Plasma Coenzyme Q10 Response to Oral Ingestion of Coenzyme Q10 Formulations." Mitochondrion, vol. 7 Suppl, 2007, pp. S78-88.
Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007;7 Suppl:S78-88.
Bhagavan, H. N., & Chopra, R. K. (2007). Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion, 7 Suppl, pp. S78-88.
Bhagavan HN, Chopra RK. Plasma Coenzyme Q10 Response to Oral Ingestion of Coenzyme Q10 Formulations. Mitochondrion. 2007;7 Suppl:S78-88. PubMed PMID: 17482886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. AU - Bhagavan,Hemmi N, AU - Chopra,Raj K, Y1 - 2007/03/27/ PY - 2006/10/23/received PY - 2007/02/21/revised PY - 2007/03/20/accepted PY - 2007/5/8/pubmed PY - 2007/9/15/medline PY - 2007/5/8/entrez SP - S78 EP - 88 JF - Mitochondrion JO - Mitochondrion VL - 7 Suppl N2 - Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a dose of 2400 mg using one specific chewable tablet formulation. The efficiency of absorption decreases as the dose increases. About 95% of circulating CoQ10 occurs as ubiquinol, with no appreciable change in the ratio following CoQ10 ingestion. Higher plasma CoQ10 concentrations are necessary to facilitate uptake by peripheral tissues and also the brain. Solubilized formulations of CoQ10 (both ubiquinone and ubiquinol) have superior bioavailability as evidenced by their enhanced plasma CoQ10 responses. SN - 1567-7249 UR - https://www.unboundmedicine.com/medline/citation/17482886/Plasma_coenzyme_Q10_response_to_oral_ingestion_of_coenzyme_Q10_formulations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-7249(07)00061-X DB - PRIME DP - Unbound Medicine ER -