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Degradation and drug release properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate).
J Mater Sci Mater Med 2007; 18(9):1765-9JM

Abstract

A series of biodegradable amphiphilic graft copolymers with poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) as the backbone and poly(2,2-dimethyltrimethylene carbonate) (PDTC) segments with different lengths as the grafted branches were synthesized and characterized. The in vitro degradation of the obtained PHEA-g-PDTC copolymers was studied. With particular branch lengths, PHEA-g-PDTC can form self-assembling micelles in an aqueous solution. Transmission electron microscopy (TEM) images demonstrated that the micelles were regularly spherical in shape. The particle size and distribution of the micelles were measured. Nanoparticle drug delivery systems were prepared by the direct dissolution method. The in vitro release behaviors of two drugs, prednisone acetate and tegafur, with different water solubilities were investigated.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17483907

Citation

Peng, Tao, et al. "Degradation and Drug Release Properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene Carbonate)." Journal of Materials Science. Materials in Medicine, vol. 18, no. 9, 2007, pp. 1765-9.
Peng T, Su J, Cheng SX, et al. Degradation and drug release properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate). J Mater Sci Mater Med. 2007;18(9):1765-9.
Peng, T., Su, J., Cheng, S. X., & Zhuo, R. X. (2007). Degradation and drug release properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate). Journal of Materials Science. Materials in Medicine, 18(9), pp. 1765-9.
Peng T, et al. Degradation and Drug Release Properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene Carbonate). J Mater Sci Mater Med. 2007;18(9):1765-9. PubMed PMID: 17483907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degradation and drug release properties of poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(2,2-dimethyltrimethylene carbonate). AU - Peng,Tao, AU - Su,Jing, AU - Cheng,Si-Xue, AU - Zhuo,Ren-Xi, Y1 - 2007/05/05/ PY - 2005/08/08/received PY - 2006/05/05/accepted PY - 2007/5/8/pubmed PY - 2007/12/6/medline PY - 2007/5/8/entrez SP - 1765 EP - 9 JF - Journal of materials science. Materials in medicine JO - J Mater Sci Mater Med VL - 18 IS - 9 N2 - A series of biodegradable amphiphilic graft copolymers with poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) as the backbone and poly(2,2-dimethyltrimethylene carbonate) (PDTC) segments with different lengths as the grafted branches were synthesized and characterized. The in vitro degradation of the obtained PHEA-g-PDTC copolymers was studied. With particular branch lengths, PHEA-g-PDTC can form self-assembling micelles in an aqueous solution. Transmission electron microscopy (TEM) images demonstrated that the micelles were regularly spherical in shape. The particle size and distribution of the micelles were measured. Nanoparticle drug delivery systems were prepared by the direct dissolution method. The in vitro release behaviors of two drugs, prednisone acetate and tegafur, with different water solubilities were investigated. SN - 0957-4530 UR - https://www.unboundmedicine.com/medline/citation/17483907/Degradation_and_drug_release_properties_of_poly_alphabeta_[N__2_hydroxyethyl__L_aspartamide]_g_poly_22_dimethyltrimethylene_carbonate__ L2 - https://doi.org/10.1007/s10856-007-3022-9 DB - PRIME DP - Unbound Medicine ER -