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Obesity and risk of non-Hodgkin lymphoma (United States).
Cancer Causes Control 2007; 18(6):677-85CC

Abstract

OBJECTIVE

Few studies have explored the potential association between body mass index (BMI) and non-Hodgkin lymphoma (NHL) according to histologic subtypes, or have evaluated BMI at different periods in the subject's life, and the results of these studies have been inconsistent.

SUBJECTS

A population-based, case-control study of 387 patients with NHL and 535 controls conducted in Nebraska between 1999 and 2002.

METHODS

Information on usual adult weight, weight at the ages 20-29, 40-49, and 60-69 years, height, physical activity, and other lifestyle factors was collected by telephone interview. A self-administered semi-quantitative food frequency questionnaire was used to collect dietary intake. Risk was estimated by odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, total energy intake, physical activity, and other confounding factors.

RESULTS

Higher adult BMI was associated with risk of NHL (OR=1.4; 95% CI=0.9-2.0) comparing the obese group (BMI >or= 30.0 kg/m(2)) with the normal weight group (BMI=18.5-24.9 kg/m(2)). The risk was higher for those who were class 2 obese (BMI >or= 35.0 kg/m(2), OR=1.7; 95% CI=1.0-2.9). The positive association was similar among men and women. An excess risk of NHL was associated with high BMI at ages 40-49 years (OR=1.6; 95% CI=1.0-2.5), and to a lesser extent, at ages 20-29 years (OR=1.4; 95% CI=0.8-2.5). Obesity at ages 40-49 years was also associated with a higher risk of small lymphocytic lymphoma (OR=4.5; 95% CI=1.5-13.3), diffuse large B-cell NHL (OR=1.8; 95% CI=0.9-3.9) and follicular NHL (OR=1.8; 95% CI=0.9-3.5).

CONCLUSION

Obesity is associated with risk of NHL overall. Obesity at ages 40-49 years is also associated with a higher risk of NHL overall, and particularly small lymphocytic, follicular, and diffuse large B-cell NHL.

Authors+Show Affiliations

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611-4402, USA. bchiu@northwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17484069

Citation

Chiu, Brian C-H, et al. "Obesity and Risk of non-Hodgkin Lymphoma (United States)." Cancer Causes & Control : CCC, vol. 18, no. 6, 2007, pp. 677-85.
Chiu BC, Soni L, Gapstur SM, et al. Obesity and risk of non-Hodgkin lymphoma (United States). Cancer Causes Control. 2007;18(6):677-85.
Chiu, B. C., Soni, L., Gapstur, S. M., Fought, A. J., Evens, A. M., & Weisenburger, D. D. (2007). Obesity and risk of non-Hodgkin lymphoma (United States). Cancer Causes & Control : CCC, 18(6), pp. 677-85.
Chiu BC, et al. Obesity and Risk of non-Hodgkin Lymphoma (United States). Cancer Causes Control. 2007;18(6):677-85. PubMed PMID: 17484069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and risk of non-Hodgkin lymphoma (United States). AU - Chiu,Brian C-H, AU - Soni,Lori, AU - Gapstur,Susan M, AU - Fought,Angela J, AU - Evens,Andrew M, AU - Weisenburger,Dennis D, Y1 - 2007/05/07/ PY - 2007/01/09/received PY - 2007/04/02/accepted PY - 2007/5/8/pubmed PY - 2007/8/10/medline PY - 2007/5/8/entrez SP - 677 EP - 85 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 6 N2 - OBJECTIVE: Few studies have explored the potential association between body mass index (BMI) and non-Hodgkin lymphoma (NHL) according to histologic subtypes, or have evaluated BMI at different periods in the subject's life, and the results of these studies have been inconsistent. SUBJECTS: A population-based, case-control study of 387 patients with NHL and 535 controls conducted in Nebraska between 1999 and 2002. METHODS: Information on usual adult weight, weight at the ages 20-29, 40-49, and 60-69 years, height, physical activity, and other lifestyle factors was collected by telephone interview. A self-administered semi-quantitative food frequency questionnaire was used to collect dietary intake. Risk was estimated by odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, total energy intake, physical activity, and other confounding factors. RESULTS: Higher adult BMI was associated with risk of NHL (OR=1.4; 95% CI=0.9-2.0) comparing the obese group (BMI >or= 30.0 kg/m(2)) with the normal weight group (BMI=18.5-24.9 kg/m(2)). The risk was higher for those who were class 2 obese (BMI >or= 35.0 kg/m(2), OR=1.7; 95% CI=1.0-2.9). The positive association was similar among men and women. An excess risk of NHL was associated with high BMI at ages 40-49 years (OR=1.6; 95% CI=1.0-2.5), and to a lesser extent, at ages 20-29 years (OR=1.4; 95% CI=0.8-2.5). Obesity at ages 40-49 years was also associated with a higher risk of small lymphocytic lymphoma (OR=4.5; 95% CI=1.5-13.3), diffuse large B-cell NHL (OR=1.8; 95% CI=0.9-3.9) and follicular NHL (OR=1.8; 95% CI=0.9-3.5). CONCLUSION: Obesity is associated with risk of NHL overall. Obesity at ages 40-49 years is also associated with a higher risk of NHL overall, and particularly small lymphocytic, follicular, and diffuse large B-cell NHL. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17484069/Obesity_and_risk_of_non_Hodgkin_lymphoma__United_States__ L2 - https://doi.org/10.1007/s10552-007-9013-9 DB - PRIME DP - Unbound Medicine ER -