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Influence of water soluble polymers on hydroxypropyl-beta-cyclodextrin complexation of rofecoxib.
Pharmazie. 2007 Apr; 62(4):284-6.P

Abstract

Rofecoxib (Rb) is a nonsteroidal anti-inflammatory drug (NSAID) with poor aqueous solubility. The present study was undertaken to investigate the influence of water-soluble polymers namely sodium carboxymethyl cellulose (Na CMC), polyvinylpyrrolidine (PVP) and polyethylene glycol (PEG-6000) on hydroxypropyl beta-cyclodextrin (HP beta-CD) complexation of Rb. The complexes were prepared by kneading, autoclaving and precipitation techniques in 1:1 and 1:2 molar ratios. The aqueous solubility enhancement of Rb by these polymers is found to be of the following order: Na CMC > PVP > PEG-6000. Complexes were characterized by Fourier transform infrared (FTIR) spectroscopy, Nuclear magnetic resonance (NMR) and X-ray diffractometry (XRD) techniques. In vitro dissolution studies were carried out on tablets formulated from molar ratios of the complexes prepared by different techniques.

Authors+Show Affiliations

Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17484284

Citation

Singh, I, and H Y. Aboul-Enein. "Influence of Water Soluble Polymers On Hydroxypropyl-beta-cyclodextrin Complexation of Rofecoxib." Die Pharmazie, vol. 62, no. 4, 2007, pp. 284-6.
Singh I, Aboul-Enein HY. Influence of water soluble polymers on hydroxypropyl-beta-cyclodextrin complexation of rofecoxib. Pharmazie. 2007;62(4):284-6.
Singh, I., & Aboul-Enein, H. Y. (2007). Influence of water soluble polymers on hydroxypropyl-beta-cyclodextrin complexation of rofecoxib. Die Pharmazie, 62(4), 284-6.
Singh I, Aboul-Enein HY. Influence of Water Soluble Polymers On Hydroxypropyl-beta-cyclodextrin Complexation of Rofecoxib. Pharmazie. 2007;62(4):284-6. PubMed PMID: 17484284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of water soluble polymers on hydroxypropyl-beta-cyclodextrin complexation of rofecoxib. AU - Singh,I, AU - Aboul-Enein,H Y, PY - 2007/5/9/pubmed PY - 2007/6/6/medline PY - 2007/5/9/entrez SP - 284 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 62 IS - 4 N2 - Rofecoxib (Rb) is a nonsteroidal anti-inflammatory drug (NSAID) with poor aqueous solubility. The present study was undertaken to investigate the influence of water-soluble polymers namely sodium carboxymethyl cellulose (Na CMC), polyvinylpyrrolidine (PVP) and polyethylene glycol (PEG-6000) on hydroxypropyl beta-cyclodextrin (HP beta-CD) complexation of Rb. The complexes were prepared by kneading, autoclaving and precipitation techniques in 1:1 and 1:2 molar ratios. The aqueous solubility enhancement of Rb by these polymers is found to be of the following order: Na CMC > PVP > PEG-6000. Complexes were characterized by Fourier transform infrared (FTIR) spectroscopy, Nuclear magnetic resonance (NMR) and X-ray diffractometry (XRD) techniques. In vitro dissolution studies were carried out on tablets formulated from molar ratios of the complexes prepared by different techniques. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/17484284/Influence_of_water_soluble_polymers_on_hydroxypropyl_beta_cyclodextrin_complexation_of_rofecoxib_ L2 - https://antibodies.cancer.gov/detail/CPTC-DLC1-1 DB - PRIME DP - Unbound Medicine ER -