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Coenzyme Q treatment of neurodegenerative diseases of aging.
Mitochondrion. 2007 Jun; 7 Suppl:S146-53.M

Abstract

The etiology of several neurodegenerative disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q-10 (CoQ10) acts both as an antioxidant and as an electron acceptor at the level of the mitochondria. In several animal models of neurodegenerative diseases including amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease, CoQ10 has shown beneficial effects. Based on its biochemical properties and the effects in animal models, several clinical trials evaluating CoQ10 have been undertaken in many neurodegenerative diseases. CoQ10 appears to be safe and well tolerated, and several efficacy trials are planned.

Authors+Show Affiliations

National Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Blvd., Room 2225, Bethesda, MD 20892, USA. galpernw@ninds.nih.govNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17485247

Citation

Galpern, Wendy R., and Merit E. Cudkowicz. "Coenzyme Q Treatment of Neurodegenerative Diseases of Aging." Mitochondrion, vol. 7 Suppl, 2007, pp. S146-53.
Galpern WR, Cudkowicz ME. Coenzyme Q treatment of neurodegenerative diseases of aging. Mitochondrion. 2007;7 Suppl:S146-53.
Galpern, W. R., & Cudkowicz, M. E. (2007). Coenzyme Q treatment of neurodegenerative diseases of aging. Mitochondrion, 7 Suppl, S146-53.
Galpern WR, Cudkowicz ME. Coenzyme Q Treatment of Neurodegenerative Diseases of Aging. Mitochondrion. 2007;7 Suppl:S146-53. PubMed PMID: 17485247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q treatment of neurodegenerative diseases of aging. AU - Galpern,Wendy R, AU - Cudkowicz,Merit E, Y1 - 2007/03/27/ PY - 2006/10/26/received PY - 2007/01/29/accepted PY - 2007/5/9/pubmed PY - 2007/9/15/medline PY - 2007/5/9/entrez SP - S146 EP - 53 JF - Mitochondrion JO - Mitochondrion VL - 7 Suppl N2 - The etiology of several neurodegenerative disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q-10 (CoQ10) acts both as an antioxidant and as an electron acceptor at the level of the mitochondria. In several animal models of neurodegenerative diseases including amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease, CoQ10 has shown beneficial effects. Based on its biochemical properties and the effects in animal models, several clinical trials evaluating CoQ10 have been undertaken in many neurodegenerative diseases. CoQ10 appears to be safe and well tolerated, and several efficacy trials are planned. SN - 1567-7249 UR - https://www.unboundmedicine.com/medline/citation/17485247/Coenzyme_Q_treatment_of_neurodegenerative_diseases_of_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-7249(07)00058-X DB - PRIME DP - Unbound Medicine ER -