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[Two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease after clinical courses of 26 years].
Nihon Shokakibyo Gakkai Zasshi 2007; 104(5):690-7NS

Abstract

We report two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease. Case 1 was a 68-year-old woman, and case 2 was a 46-year-old man. They were admitted to our department for evaluation and treatment of HCC. The causes of the underlying liver disease were not determined from blood tests. However, histological analysis of non-tumor tissues of the liver revealed cirrhosis with few fat droplets. Both patients had undergone liver biopsy 26 years before the treatment of HCC. Histological review of the biopsy specimens revealed NASH (case 1) and fatty liver (case 2), respectively. It was suggested that these cases progressed from NASH and fatty liver, respectively, to NASH-related cirrhosis (so called burned-out NASH), eventually, developing HCC. These findings suggest that substantial number of burned-out NASH cases may be included in those with cryptogenic cirrhosis. These two patients are indicative cases that may reveal the long-term natural course of fatty liver and NASH.

Authors+Show Affiliations

Department of Gastroenterology, Iwaki Kyoritsu General Hospital, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

17485950

Citation

Tsutsumi, Koichiro, et al. "[Two Cases of Patients With Hepatocellular Carcinoma (HCC) That Developed in Cryptogenic Cirrhosis Suggestive of Nonalcoholic Steatohepatitis (NASH) as Background Liver Disease After Clinical Courses of 26 Years]." Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-enterology, vol. 104, no. 5, 2007, pp. 690-7.
Tsutsumi K, Nakayama H, Sakai Y, et al. [Two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease after clinical courses of 26 years]. Nihon Shokakibyo Gakkai Zasshi. 2007;104(5):690-7.
Tsutsumi, K., Nakayama, H., Sakai, Y., Kojima, Y., Dairaku, N., Ojima, T., ... Hiwatashi, N. (2007). [Two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease after clinical courses of 26 years]. Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-enterology, 104(5), pp. 690-7.
Tsutsumi K, et al. [Two Cases of Patients With Hepatocellular Carcinoma (HCC) That Developed in Cryptogenic Cirrhosis Suggestive of Nonalcoholic Steatohepatitis (NASH) as Background Liver Disease After Clinical Courses of 26 Years]. Nihon Shokakibyo Gakkai Zasshi. 2007;104(5):690-7. PubMed PMID: 17485950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease after clinical courses of 26 years]. AU - Tsutsumi,Koichiro, AU - Nakayama,Haruo, AU - Sakai,Yoshitaka, AU - Kojima,Yasuhiro, AU - Dairaku,Naohiro, AU - Ojima,Toshiaki, AU - Kusano,Masao, AU - Ikeya,Shinichi, AU - Sugai,Yoshiki, AU - Hiwatashi,Nobuo, PY - 2007/5/9/pubmed PY - 2007/7/4/medline PY - 2007/5/9/entrez SP - 690 EP - 7 JF - Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology JO - Nihon Shokakibyo Gakkai Zasshi VL - 104 IS - 5 N2 - We report two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease. Case 1 was a 68-year-old woman, and case 2 was a 46-year-old man. They were admitted to our department for evaluation and treatment of HCC. The causes of the underlying liver disease were not determined from blood tests. However, histological analysis of non-tumor tissues of the liver revealed cirrhosis with few fat droplets. Both patients had undergone liver biopsy 26 years before the treatment of HCC. Histological review of the biopsy specimens revealed NASH (case 1) and fatty liver (case 2), respectively. It was suggested that these cases progressed from NASH and fatty liver, respectively, to NASH-related cirrhosis (so called burned-out NASH), eventually, developing HCC. These findings suggest that substantial number of burned-out NASH cases may be included in those with cryptogenic cirrhosis. These two patients are indicative cases that may reveal the long-term natural course of fatty liver and NASH. SN - 0446-6586 UR - https://www.unboundmedicine.com/medline/citation/17485950/[Two_cases_of_patients_with_hepatocellular_carcinoma__HCC__that_developed_in_cryptogenic_cirrhosis_suggestive_of_nonalcoholic_steatohepatitis__NASH__as_background_liver_disease_after_clinical_courses_of_26_years]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/nisshoshi/104.690?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -