Mitochondria and neurodegeneration.Biosci Rep. 2007 Jun; 27(1-3):87-104.BR
Abstract
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?" is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration.
Links
MeSH
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
17486441
Citation
Petrozzi, Lucia, et al. "Mitochondria and Neurodegeneration." Bioscience Reports, vol. 27, no. 1-3, 2007, pp. 87-104.
Petrozzi L, Ricci G, Giglioli NJ, et al. Mitochondria and neurodegeneration. Biosci Rep. 2007;27(1-3):87-104.
Petrozzi, L., Ricci, G., Giglioli, N. J., Siciliano, G., & Mancuso, M. (2007). Mitochondria and neurodegeneration. Bioscience Reports, 27(1-3), 87-104.
Petrozzi L, et al. Mitochondria and Neurodegeneration. Biosci Rep. 2007;27(1-3):87-104. PubMed PMID: 17486441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Mitochondria and neurodegeneration.
AU - Petrozzi,Lucia,
AU - Ricci,Giulia,
AU - Giglioli,Noemi J,
AU - Siciliano,Gabriele,
AU - Mancuso,Michelangelo,
PY - 2007/5/9/pubmed
PY - 2007/8/7/medline
PY - 2007/5/9/entrez
SP - 87
EP - 104
JF - Bioscience reports
JO - Biosci Rep
VL - 27
IS - 1-3
N2 - Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?" is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration.
SN - 0144-8463
UR - https://www.unboundmedicine.com/medline/citation/17486441/Mitochondria_and_neurodegeneration_
L2 - https://portlandpress.com/bioscirep/article-lookup/doi/10.1007/s10540-007-9038-z
DB - PRIME
DP - Unbound Medicine
ER -