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Mitochondria and neurodegeneration.
Biosci Rep. 2007 Jun; 27(1-3):87-104.BR

Abstract

Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?" is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration.

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Authors+Show Affiliations

Petrozzi L
Department of Neuroscience, University of Pisa, Via Roma 67, Pisa, 56126, Italy. mmancuso@inwind.it
Ricci G
No affiliation info available
Giglioli NJ
No affiliation info available
Siciliano G
No affiliation info available
Mancuso M
No affiliation info available

MeSH

Alzheimer DiseaseAmyotrophic Lateral SclerosisDNA, MitochondrialHumansHuntington DiseaseMitochondriaMutationNeurodegenerative DiseasesParkinson Disease

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17486441

Citation

Petrozzi, Lucia, et al. "Mitochondria and Neurodegeneration." Bioscience Reports, vol. 27, no. 1-3, 2007, pp. 87-104.
Petrozzi L, Ricci G, Giglioli NJ, et al. Mitochondria and neurodegeneration. Biosci Rep. 2007;27(1-3):87-104.
Petrozzi, L., Ricci, G., Giglioli, N. J., Siciliano, G., & Mancuso, M. (2007). Mitochondria and neurodegeneration. Bioscience Reports, 27(1-3), 87-104.
Petrozzi L, et al. Mitochondria and Neurodegeneration. Biosci Rep. 2007;27(1-3):87-104. PubMed PMID: 17486441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondria and neurodegeneration. AU - Petrozzi,Lucia, AU - Ricci,Giulia, AU - Giglioli,Noemi J, AU - Siciliano,Gabriele, AU - Mancuso,Michelangelo, PY - 2007/5/9/pubmed PY - 2007/8/7/medline PY - 2007/5/9/entrez SP - 87 EP - 104 JF - Bioscience reports JO - Biosci Rep VL - 27 IS - 1-3 N2 - Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?" is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration. SN - 0144-8463 UR - https://www.unboundmedicine.com/medline/citation/17486441/Mitochondria_and_neurodegeneration_ L2 - https://portlandpress.com/bioscirep/article-lookup/doi/10.1007/s10540-007-9038-z DB - PRIME DP - Unbound Medicine ER -