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Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment.
Eur J Clin Nutr. 2008 Feb; 62(2):263-73.EJ

Abstract

OBJECTIVE

The present study was designed to examine for the first time, side-by-side, the effects of plant sterol and stanol consumption on lipid metabolism and markers of antioxidant status, oxidative stress, endothelial dysfunction and low-grade inflammation in subjects on stable statin-treatment.

DESIGN

Double-blind, randomized, placebo-controlled, intervention trial.

SETTING

University.

SUBJECTS

Forty-five patients on current statin treatment were recruited via newspaper advertisements. Data of 41 patients were used in statistical analysis.

INTERVENTION

Subjects consumed margarine with no added plant sterols or stanols for 4 weeks and were then divided into three groups of 15 subjects. For the next 16 weeks, one group continued with the control margarine and the other two groups with either a plant sterol- or stanol (2.5 g/day)-enriched margarine. Blood was sampled at the end of the run-in and intervention periods.

RESULTS

Plant sterol and stanol consumption significantly (P=0.026) reduced low-density lipoprotein (LDL) cholesterol by 0.34 mmol/l (95% confidence interval (CI), -0.67 to -0.04 mmol/l). No effects were shown on enzymatic and non-enzymatic antioxidants and markers of oxidative modification of lipids and DNA. In addition, no effect was found on soluble adhesion molecules, C-reactive protein and monocyte chemotactic protein-1 concentrations.

CONCLUSIONS

We conclude that 16 weeks of plant sterol or stanol consumption did not affect markers of antioxidant status, oxidative stress, endothelial dysfunction and low-grade inflammation in patients on stable statin treatment, despite a significant reduction of LDL cholesterol.

Authors+Show Affiliations

Department of Human Biology, Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17487211

Citation

De Jong, A, et al. "Effects of Plant Sterol and Stanol Ester Consumption On Lipid Metabolism, Antioxidant Status and Markers of Oxidative Stress, Endothelial Function and Low-grade Inflammation in Patients On Current Statin Treatment." European Journal of Clinical Nutrition, vol. 62, no. 2, 2008, pp. 263-73.
De Jong A, Plat J, Bast A, et al. Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment. Eur J Clin Nutr. 2008;62(2):263-73.
De Jong, A., Plat, J., Bast, A., Godschalk, R. W., Basu, S., & Mensink, R. P. (2008). Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment. European Journal of Clinical Nutrition, 62(2), 263-73.
De Jong A, et al. Effects of Plant Sterol and Stanol Ester Consumption On Lipid Metabolism, Antioxidant Status and Markers of Oxidative Stress, Endothelial Function and Low-grade Inflammation in Patients On Current Statin Treatment. Eur J Clin Nutr. 2008;62(2):263-73. PubMed PMID: 17487211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment. AU - De Jong,A, AU - Plat,J, AU - Bast,A, AU - Godschalk,R W L, AU - Basu,S, AU - Mensink,R P, Y1 - 2007/05/09/ PY - 2007/5/10/pubmed PY - 2008/5/13/medline PY - 2007/5/10/entrez SP - 263 EP - 73 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 2 N2 - OBJECTIVE: The present study was designed to examine for the first time, side-by-side, the effects of plant sterol and stanol consumption on lipid metabolism and markers of antioxidant status, oxidative stress, endothelial dysfunction and low-grade inflammation in subjects on stable statin-treatment. DESIGN: Double-blind, randomized, placebo-controlled, intervention trial. SETTING: University. SUBJECTS: Forty-five patients on current statin treatment were recruited via newspaper advertisements. Data of 41 patients were used in statistical analysis. INTERVENTION: Subjects consumed margarine with no added plant sterols or stanols for 4 weeks and were then divided into three groups of 15 subjects. For the next 16 weeks, one group continued with the control margarine and the other two groups with either a plant sterol- or stanol (2.5 g/day)-enriched margarine. Blood was sampled at the end of the run-in and intervention periods. RESULTS: Plant sterol and stanol consumption significantly (P=0.026) reduced low-density lipoprotein (LDL) cholesterol by 0.34 mmol/l (95% confidence interval (CI), -0.67 to -0.04 mmol/l). No effects were shown on enzymatic and non-enzymatic antioxidants and markers of oxidative modification of lipids and DNA. In addition, no effect was found on soluble adhesion molecules, C-reactive protein and monocyte chemotactic protein-1 concentrations. CONCLUSIONS: We conclude that 16 weeks of plant sterol or stanol consumption did not affect markers of antioxidant status, oxidative stress, endothelial dysfunction and low-grade inflammation in patients on stable statin treatment, despite a significant reduction of LDL cholesterol. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17487211/Effects_of_plant_sterol_and_stanol_ester_consumption_on_lipid_metabolism_antioxidant_status_and_markers_of_oxidative_stress_endothelial_function_and_low_grade_inflammation_in_patients_on_current_statin_treatment_ L2 - https://doi.org/10.1038/sj.ejcn.1602733 DB - PRIME DP - Unbound Medicine ER -