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The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, IGF-I and IGFBP-3.
Eur J Clin Nutr. 2008 Feb; 62(2):186-96.EJ

Abstract

OBJECTIVE

To determine the effects of dietary change on serum concentrations of insulin, glucose, IGF-I and IGFBP-3.

SUBJECTS

From among participants in a randomized clinical trial of men and women without a history of diabetes who were 35 years old or older and who had at least one histologically confirmed colorectal adenoma removed during a qualifying colonoscopy within the 6 months before randomization, 750 subjects were selected for this analysis.

METHODS

The authors analyzed fasting serum from 375 subjects with and 375 subjects without a recurrent polyp among participants in a randomized trial of a low-fat (20% of energy), high-fiber (18 g per 1000 kcals of energy intake) and high-fruit and -vegetable (5-8 servings per day) dietary intervention.

RESULTS

After 4 years of follow-up, IGF-I concentration in the intervention group (N=248) declined by 8.86 ng/ml (initial mean of 133 ng/ml) and 7.74 ng/ml (initial mean value of 139 ng/ml) in the non-intervention group (N=502). Based on an unpaired t-test, these declines were both statistically significant, but the difference between groups for the decline in IGF-I (1.12 ng/ml ((95% confidence interval, -3.24 to 5.48)) was not. After 4 years, concentrations of IGFBP-3, insulin and glucose were not statistically different from values at baseline, and there were no differences in these serum measures between the intervention and control groups. In analysis restricted to lean (body mass index <25 kg/m(2)) subjects only, however, glucose concentrations in the intervention group decreased by 0.28 mmol/l, while they increased in the control group by 0.01 mmol/l (t-test for mean differences P=0.0003) over 4 years.

CONCLUSIONS

A low-fat, high-fiber, high-fruit and -vegetable dietary intervention had minimal impact on serum concentrations of insulin, glucose, IGF-I and IGFBP-3 overall, but in lean subjects the intervention resulted in a significant reduction in serum glucose concentration.

Authors+Show Affiliations

Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA. flood@epi.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17487212

Citation

Flood, A, et al. "The Effects of a High-fruit and -vegetable, High-fiber, Low-fat Dietary Intervention On Serum Concentrations of Insulin, Glucose, IGF-I and IGFBP-3." European Journal of Clinical Nutrition, vol. 62, no. 2, 2008, pp. 186-96.
Flood A, Mai V, Pfeiffer R, et al. The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, IGF-I and IGFBP-3. Eur J Clin Nutr. 2008;62(2):186-96.
Flood, A., Mai, V., Pfeiffer, R., Kahle, L., Remaley, A. T., Rosen, C. J., Lanza, E., & Schatzkin, A. (2008). The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, IGF-I and IGFBP-3. European Journal of Clinical Nutrition, 62(2), 186-96.
Flood A, et al. The Effects of a High-fruit and -vegetable, High-fiber, Low-fat Dietary Intervention On Serum Concentrations of Insulin, Glucose, IGF-I and IGFBP-3. Eur J Clin Nutr. 2008;62(2):186-96. PubMed PMID: 17487212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, IGF-I and IGFBP-3. AU - Flood,A, AU - Mai,V, AU - Pfeiffer,R, AU - Kahle,L, AU - Remaley,A T, AU - Rosen,C J, AU - Lanza,E, AU - Schatzkin,A, Y1 - 2007/05/09/ PY - 2007/5/10/pubmed PY - 2008/5/13/medline PY - 2007/5/10/entrez SP - 186 EP - 96 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 2 N2 - OBJECTIVE: To determine the effects of dietary change on serum concentrations of insulin, glucose, IGF-I and IGFBP-3. SUBJECTS: From among participants in a randomized clinical trial of men and women without a history of diabetes who were 35 years old or older and who had at least one histologically confirmed colorectal adenoma removed during a qualifying colonoscopy within the 6 months before randomization, 750 subjects were selected for this analysis. METHODS: The authors analyzed fasting serum from 375 subjects with and 375 subjects without a recurrent polyp among participants in a randomized trial of a low-fat (20% of energy), high-fiber (18 g per 1000 kcals of energy intake) and high-fruit and -vegetable (5-8 servings per day) dietary intervention. RESULTS: After 4 years of follow-up, IGF-I concentration in the intervention group (N=248) declined by 8.86 ng/ml (initial mean of 133 ng/ml) and 7.74 ng/ml (initial mean value of 139 ng/ml) in the non-intervention group (N=502). Based on an unpaired t-test, these declines were both statistically significant, but the difference between groups for the decline in IGF-I (1.12 ng/ml ((95% confidence interval, -3.24 to 5.48)) was not. After 4 years, concentrations of IGFBP-3, insulin and glucose were not statistically different from values at baseline, and there were no differences in these serum measures between the intervention and control groups. In analysis restricted to lean (body mass index <25 kg/m(2)) subjects only, however, glucose concentrations in the intervention group decreased by 0.28 mmol/l, while they increased in the control group by 0.01 mmol/l (t-test for mean differences P=0.0003) over 4 years. CONCLUSIONS: A low-fat, high-fiber, high-fruit and -vegetable dietary intervention had minimal impact on serum concentrations of insulin, glucose, IGF-I and IGFBP-3 overall, but in lean subjects the intervention resulted in a significant reduction in serum glucose concentration. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17487212/The_effects_of_a_high_fruit_and__vegetable_high_fiber_low_fat_dietary_intervention_on_serum_concentrations_of_insulin_glucose_IGF_I_and_IGFBP_3_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602726 DB - PRIME DP - Unbound Medicine ER -