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Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals.
Can J Physiol Pharmacol. 2006 Dec; 84(12):1291-9.CJ

Abstract

The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments.

Authors+Show Affiliations

Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A 7/A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia. shaza8174@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17487238

Citation

Zakaria, Z A., et al. "Antinociceptive, Anti-inflammatory and Antipyretic Properties of Melastoma Malabathricum Leaves Aqueous Extract in Experimental Animals." Canadian Journal of Physiology and Pharmacology, vol. 84, no. 12, 2006, pp. 1291-9.
Zakaria ZA, Raden Mohd Nor RN, Hanan Kumar G, et al. Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Can J Physiol Pharmacol. 2006;84(12):1291-9.
Zakaria, Z. A., Raden Mohd Nor, R. N., Hanan Kumar, G., Abdul Ghani, Z. D., Sulaiman, M. R., Rathna Devi, G., Mat Jais, A. M., Somchit, M. N., & Fatimah, C. A. (2006). Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Canadian Journal of Physiology and Pharmacology, 84(12), 1291-9.
Zakaria ZA, et al. Antinociceptive, Anti-inflammatory and Antipyretic Properties of Melastoma Malabathricum Leaves Aqueous Extract in Experimental Animals. Can J Physiol Pharmacol. 2006;84(12):1291-9. PubMed PMID: 17487238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. AU - Zakaria,Z A, AU - Raden Mohd Nor,R N S, AU - Hanan Kumar,G, AU - Abdul Ghani,Z D F, AU - Sulaiman,M R, AU - Rathna Devi,G, AU - Mat Jais,A M, AU - Somchit,M N, AU - Fatimah,C A, PY - 2007/5/10/pubmed PY - 2007/6/1/medline PY - 2007/5/10/entrez SP - 1291 EP - 9 JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. VL - 84 IS - 12 N2 - The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/17487238/Antinociceptive_anti_inflammatory_and_antipyretic_properties_of_Melastoma_malabathricum_leaves_aqueous_extract_in_experimental_animals_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/y06-083?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -