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Bioactive compounds in cranberries and their role in prevention of urinary tract infections.
Mol Nutr Food Res 2007; 51(6):732-7MN

Abstract

Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed.

Authors+Show Affiliations

Howell AB
Marucci Center or Blueberry and Cranberry Research and Extension, Rutgers, The State University of New Jersey, Chatsworth, NJ 08019, USA. ahowell@aesop.rutgers.edu

MeSH

AbsorptionBacterial AdhesionBeveragesEscherichia coliFruitPhytotherapyProanthocyanidinsUrinary Tract InfectionsVaccinium macrocarpon

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17487930

Citation

Howell, Amy B.. "Bioactive Compounds in Cranberries and Their Role in Prevention of Urinary Tract Infections." Molecular Nutrition & Food Research, vol. 51, no. 6, 2007, pp. 732-7.
Howell AB. Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res. 2007;51(6):732-7.
Howell, A. B. (2007). Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Molecular Nutrition & Food Research, 51(6), pp. 732-7.
Howell AB. Bioactive Compounds in Cranberries and Their Role in Prevention of Urinary Tract Infections. Mol Nutr Food Res. 2007;51(6):732-7. PubMed PMID: 17487930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive compounds in cranberries and their role in prevention of urinary tract infections. A1 - Howell,Amy B, PY - 2007/5/10/pubmed PY - 2007/8/19/medline PY - 2007/5/10/entrez SP - 732 EP - 7 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 51 IS - 6 N2 - Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/17487930/Bioactive_compounds_in_cranberries_and_their_role_in_prevention_of_urinary_tract_infections_ DB - PRIME DP - Unbound Medicine ER -