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Bioactive compounds in cranberries and their role in prevention of urinary tract infections.

Abstract

Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Marucci Center or Blueberry and Cranberry Research and Extension, Rutgers, The State University of New Jersey, Chatsworth, NJ 08019, USA. ahowell@aesop.rutgers.edu

    Source

    MeSH

    Absorption
    Bacterial Adhesion
    Beverages
    Escherichia coli
    Fruit
    Phytotherapy
    Proanthocyanidins
    Urinary Tract Infections
    Vaccinium macrocarpon

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    17487930

    Citation

    Howell, Amy B.. "Bioactive Compounds in Cranberries and Their Role in Prevention of Urinary Tract Infections." Molecular Nutrition & Food Research, vol. 51, no. 6, 2007, pp. 732-7.
    Howell AB. Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res. 2007;51(6):732-7.
    Howell, A. B. (2007). Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Molecular Nutrition & Food Research, 51(6), pp. 732-7.
    Howell AB. Bioactive Compounds in Cranberries and Their Role in Prevention of Urinary Tract Infections. Mol Nutr Food Res. 2007;51(6):732-7. PubMed PMID: 17487930.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bioactive compounds in cranberries and their role in prevention of urinary tract infections. A1 - Howell,Amy B, PY - 2007/5/10/pubmed PY - 2007/8/19/medline PY - 2007/5/10/entrez SP - 732 EP - 7 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 51 IS - 6 N2 - Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/17487930/Bioactive_compounds_in_cranberries_and_their_role_in_prevention_of_urinary_tract_infections_ L2 - https://doi.org/10.1002/mnfr.200700038 DB - PRIME DP - Unbound Medicine ER -