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Bioactive compounds in cranberries and their role in prevention of urinary tract infections.
Mol Nutr Food Res. 2007 Jun; 51(6):732-7.MN

Abstract

Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed.

Authors+Show Affiliations

Marucci Center or Blueberry and Cranberry Research and Extension, Rutgers, The State University of New Jersey, Chatsworth, NJ 08019, USA. ahowell@aesop.rutgers.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17487930

Citation

Howell, Amy B.. "Bioactive Compounds in Cranberries and Their Role in Prevention of Urinary Tract Infections." Molecular Nutrition & Food Research, vol. 51, no. 6, 2007, pp. 732-7.
Howell AB. Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Mol Nutr Food Res. 2007;51(6):732-7.
Howell, A. B. (2007). Bioactive compounds in cranberries and their role in prevention of urinary tract infections. Molecular Nutrition & Food Research, 51(6), 732-7.
Howell AB. Bioactive Compounds in Cranberries and Their Role in Prevention of Urinary Tract Infections. Mol Nutr Food Res. 2007;51(6):732-7. PubMed PMID: 17487930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioactive compounds in cranberries and their role in prevention of urinary tract infections. A1 - Howell,Amy B, PY - 2007/5/10/pubmed PY - 2007/8/19/medline PY - 2007/5/10/entrez SP - 732 EP - 7 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 51 IS - 6 N2 - Cranberry (Vaccinium macrocarpon Ait.) ingestion has long been associated with prevention of urinary tract infections. The beneficial mechanism was historically thought to be due to the fruit acids causing a bacteriostatic effect in the urine. However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity against both antibiotic susceptible and resistant strains of uropathogenic P-fimbriated Escherichia coli bacteria. The link between cranberry ingestion and maintenance of urinary tract health as well as the structural diversity, pharmacokinetics, quantification, and bacterial antiadhesion bioactivity of the A-linked cranberry PACs are reviewed. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/17487930/Bioactive_compounds_in_cranberries_and_their_role_in_prevention_of_urinary_tract_infections_ L2 - https://doi.org/10.1002/mnfr.200700038 DB - PRIME DP - Unbound Medicine ER -