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The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy.
Diabet Med 2007; 24(9):1034-8DM

Abstract

AIMS

Multiple pathogenic pathways are involved in diabetic neuropathy and diverse treatments have been tried without success. The aim of this study was to assess the effect of alpha-lipoic acid on skin blood flow in patients with diabetic neuropathy.

METHODS

We measured skin blood flow in 13 control subjects and 19 patients with diabetic neuropathy using the laser Doppler blood flow technique. Skin blood flow and the extent of skin blood flow changes were compared before and after diabetic patients received 600 mg/day alpha-lipoic acid intravenously for 14 days.

RESULTS

Although no significant differences in absolute values of skin blood flow or in the extent of changes were noted, symptoms were reduced after alpha-lipoic acid treatment.

CONCLUSIONS

This study suggests that alpha-lipoic acid, a potent antioxidant, improves symptoms of diabetic neuropathy. Larger studies are needed to determine whether improvements in skin blood flow also occur in patients with diabetic neuropathy.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University, Medical School, Jeon-ju, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17490418

Citation

Jin, H Y., et al. "The Effect of Alpha-lipoic Acid On Symptoms and Skin Blood Flow in Diabetic Neuropathy." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 24, no. 9, 2007, pp. 1034-8.
Jin HY, Joung SJ, Park JH, et al. The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy. Diabet Med. 2007;24(9):1034-8.
Jin, H. Y., Joung, S. J., Park, J. H., Baek, H. S., & Park, T. S. (2007). The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy. Diabetic Medicine : a Journal of the British Diabetic Association, 24(9), pp. 1034-8.
Jin HY, et al. The Effect of Alpha-lipoic Acid On Symptoms and Skin Blood Flow in Diabetic Neuropathy. Diabet Med. 2007;24(9):1034-8. PubMed PMID: 17490418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy. AU - Jin,H Y, AU - Joung,S J, AU - Park,J H, AU - Baek,H S, AU - Park,T S, Y1 - 2007/05/08/ PY - 2007/5/11/pubmed PY - 2007/12/11/medline PY - 2007/5/11/entrez SP - 1034 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 24 IS - 9 N2 - AIMS: Multiple pathogenic pathways are involved in diabetic neuropathy and diverse treatments have been tried without success. The aim of this study was to assess the effect of alpha-lipoic acid on skin blood flow in patients with diabetic neuropathy. METHODS: We measured skin blood flow in 13 control subjects and 19 patients with diabetic neuropathy using the laser Doppler blood flow technique. Skin blood flow and the extent of skin blood flow changes were compared before and after diabetic patients received 600 mg/day alpha-lipoic acid intravenously for 14 days. RESULTS: Although no significant differences in absolute values of skin blood flow or in the extent of changes were noted, symptoms were reduced after alpha-lipoic acid treatment. CONCLUSIONS: This study suggests that alpha-lipoic acid, a potent antioxidant, improves symptoms of diabetic neuropathy. Larger studies are needed to determine whether improvements in skin blood flow also occur in patients with diabetic neuropathy. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17490418/The_effect_of_alpha_lipoic_acid_on_symptoms_and_skin_blood_flow_in_diabetic_neuropathy_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02179.x DB - PRIME DP - Unbound Medicine ER -