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Stress and inflammation in exacerbations of asthma.
Brain Behav Immun 2007; 21(8):993-9BB

Abstract

In this mini-review, we outline a model depicting the immunologic mechanisms by which psychological stress can exacerbate clinical symptoms in patients with asthma. This model highlights the importance of both social and physical exposures in the exacerbation of asthma symptoms. The basic premise of the model is that psychological stress operates by altering the magnitude of the airway inflammatory response that irritants, allergens, and infections bring about in persons with asthma. The biological pathways for how stress amplifies the immune response to asthma triggers include the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic-adrenal-medullary (SAM) axis, and the sympathetic (SNS) and parasympathetic (PNS) arms of the autonomic nervous system. Empirical evidence for this model is reviewed, and conclusions and future research directions are discussed.

Authors+Show Affiliations

University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4. echen@psych.ubc.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17493786

Citation

Chen, Edith, and Gregory E. Miller. "Stress and Inflammation in Exacerbations of Asthma." Brain, Behavior, and Immunity, vol. 21, no. 8, 2007, pp. 993-9.
Chen E, Miller GE. Stress and inflammation in exacerbations of asthma. Brain Behav Immun. 2007;21(8):993-9.
Chen, E., & Miller, G. E. (2007). Stress and inflammation in exacerbations of asthma. Brain, Behavior, and Immunity, 21(8), pp. 993-9.
Chen E, Miller GE. Stress and Inflammation in Exacerbations of Asthma. Brain Behav Immun. 2007;21(8):993-9. PubMed PMID: 17493786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress and inflammation in exacerbations of asthma. AU - Chen,Edith, AU - Miller,Gregory E, Y1 - 2007/05/09/ PY - 2007/01/30/received PY - 2007/03/10/revised PY - 2007/03/12/accepted PY - 2007/5/12/pubmed PY - 2008/1/9/medline PY - 2007/5/12/entrez SP - 993 EP - 9 JF - Brain, behavior, and immunity JO - Brain Behav. Immun. VL - 21 IS - 8 N2 - In this mini-review, we outline a model depicting the immunologic mechanisms by which psychological stress can exacerbate clinical symptoms in patients with asthma. This model highlights the importance of both social and physical exposures in the exacerbation of asthma symptoms. The basic premise of the model is that psychological stress operates by altering the magnitude of the airway inflammatory response that irritants, allergens, and infections bring about in persons with asthma. The biological pathways for how stress amplifies the immune response to asthma triggers include the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic-adrenal-medullary (SAM) axis, and the sympathetic (SNS) and parasympathetic (PNS) arms of the autonomic nervous system. Empirical evidence for this model is reviewed, and conclusions and future research directions are discussed. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/17493786/Stress_and_inflammation_in_exacerbations_of_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(07)00076-1 DB - PRIME DP - Unbound Medicine ER -