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Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus coinfection by early plasma exchange.
J Formos Med Assoc. 2007 Feb; 106(2 Suppl):S1-6.JF

Abstract

Leptospirosis and scrub typhus coinfections have been reported in up to 41% of agricultural workers with acute leptospirosis in Thailand, but only sporadically in Taiwan. Because of the nonspecific clinical presentations, it is difficult to differentiate patients with coinfections from leptospirosis alone. However, failure to identify coinfection may lead to mortality if inappropriate antibiotics are used. We report a 31-year-old man coinfected with leptospirosis and scrub typhus, which manifested as diffuse alveolar hemorrhage and acute renal failure mimicking pulmonary-renal syndrome. The patient was treated by early plasma exchange and a 7-day course of moxifloxacin therapy. Both pulmonary hemorrhage and hypoxemia resolved substantially on the 4th day of hospitalization. He had a complete recovery from the disease after 6 weeks of hospitalization.

Authors+Show Affiliations

Division of Pulmonary Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17493889

Citation

Chen, Yun-Sung, et al. "Successful Treatment of Pulmonary Hemorrhage Associated With Leptospirosis and Scrub Typhus Coinfection By Early Plasma Exchange." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 106, no. 2 Suppl, 2007, pp. S1-6.
Chen YS, Cheng SL, Wang HC, et al. Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus coinfection by early plasma exchange. J Formos Med Assoc. 2007;106(2 Suppl):S1-6.
Chen, Y. S., Cheng, S. L., Wang, H. C., & Yang, P. C. (2007). Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus coinfection by early plasma exchange. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 106(2 Suppl), S1-6.
Chen YS, et al. Successful Treatment of Pulmonary Hemorrhage Associated With Leptospirosis and Scrub Typhus Coinfection By Early Plasma Exchange. J Formos Med Assoc. 2007;106(2 Suppl):S1-6. PubMed PMID: 17493889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful treatment of pulmonary hemorrhage associated with leptospirosis and scrub typhus coinfection by early plasma exchange. AU - Chen,Yun-Sung, AU - Cheng,Shih-Lung, AU - Wang,Hao-Chien, AU - Yang,Pan-Chyr, PY - 2007/5/12/pubmed PY - 2007/6/1/medline PY - 2007/5/12/entrez SP - S1 EP - 6 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 106 IS - 2 Suppl N2 - Leptospirosis and scrub typhus coinfections have been reported in up to 41% of agricultural workers with acute leptospirosis in Thailand, but only sporadically in Taiwan. Because of the nonspecific clinical presentations, it is difficult to differentiate patients with coinfections from leptospirosis alone. However, failure to identify coinfection may lead to mortality if inappropriate antibiotics are used. We report a 31-year-old man coinfected with leptospirosis and scrub typhus, which manifested as diffuse alveolar hemorrhage and acute renal failure mimicking pulmonary-renal syndrome. The patient was treated by early plasma exchange and a 7-day course of moxifloxacin therapy. Both pulmonary hemorrhage and hypoxemia resolved substantially on the 4th day of hospitalization. He had a complete recovery from the disease after 6 weeks of hospitalization. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/17493889/Successful_treatment_of_pulmonary_hemorrhage_associated_with_leptospirosis_and_scrub_typhus_coinfection_by_early_plasma_exchange_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(09)60344-2 DB - PRIME DP - Unbound Medicine ER -