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Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells.
J Virol. 2007 Jul; 81(14):7338-50.JV

Abstract

Viral infections in human infants frequently follow a protracted course, with higher viral loads and delayed viral clearance compared to viral infections in older children. To identify the mechanisms responsible for this protracted pattern of infection, we developed an infant infection murine model using the well-characterized lymphocytic choriomeningitis virus (LCMV) WE strain in 2-week-old BALB/c mice. In contrast to adult mice, in which viral clearance occurred as expected 8 days after infection, LCMV titers persisted for several weeks after infection of infant mice. LCMV-specific effector CD8(+) T cells were elicited in infant mice and fully functional on day 7 but rapidly waned and could not be recovered from day 12 onwards. We show here that this results from the failure of LCMV-specific CD8(+) T cells to expand and the absence of protective LCMV-specific memory CD8(+) T cells. Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection.

Authors+Show Affiliations

World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17494081

Citation

Belnoue, Elodie, et al. "Protracted Course of Lymphocytic Choriomeningitis Virus WE Infection in Early Life: Induction but Limited Expansion of CD8+ Effector T Cells and Absence of Memory CD8+ T Cells." Journal of Virology, vol. 81, no. 14, 2007, pp. 7338-50.
Belnoue E, Fontannaz-Bozzotti P, Grillet S, et al. Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells. J Virol. 2007;81(14):7338-50.
Belnoue, E., Fontannaz-Bozzotti, P., Grillet, S., Lambert, P. H., & Siegrist, C. A. (2007). Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells. Journal of Virology, 81(14), 7338-50.
Belnoue E, et al. Protracted Course of Lymphocytic Choriomeningitis Virus WE Infection in Early Life: Induction but Limited Expansion of CD8+ Effector T Cells and Absence of Memory CD8+ T Cells. J Virol. 2007;81(14):7338-50. PubMed PMID: 17494081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells. AU - Belnoue,Elodie, AU - Fontannaz-Bozzotti,Paola, AU - Grillet,Stéphane, AU - Lambert,Paul-Henri, AU - Siegrist,Claire-Anne, Y1 - 2007/05/09/ PY - 2007/5/12/pubmed PY - 2007/9/15/medline PY - 2007/5/12/entrez SP - 7338 EP - 50 JF - Journal of virology JO - J Virol VL - 81 IS - 14 N2 - Viral infections in human infants frequently follow a protracted course, with higher viral loads and delayed viral clearance compared to viral infections in older children. To identify the mechanisms responsible for this protracted pattern of infection, we developed an infant infection murine model using the well-characterized lymphocytic choriomeningitis virus (LCMV) WE strain in 2-week-old BALB/c mice. In contrast to adult mice, in which viral clearance occurred as expected 8 days after infection, LCMV titers persisted for several weeks after infection of infant mice. LCMV-specific effector CD8(+) T cells were elicited in infant mice and fully functional on day 7 but rapidly waned and could not be recovered from day 12 onwards. We show here that this results from the failure of LCMV-specific CD8(+) T cells to expand and the absence of protective LCMV-specific memory CD8(+) T cells. Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/17494081/Protracted_course_of_lymphocytic_choriomeningitis_virus_WE_infection_in_early_life:_induction_but_limited_expansion_of_CD8+_effector_T_cells_and_absence_of_memory_CD8+_T_cells_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=17494081 DB - PRIME DP - Unbound Medicine ER -