TY - JOUR T1 - Needle-free skin patch delivery of a vaccine for a potentially pandemic influenza virus provides protection against lethal challenge in mice. AU - Garg,Sanjay, AU - Hoelscher,Mary, AU - Belser,Jessica A, AU - Wang,Chong, AU - Jayashankar,Lakshmi, AU - Guo,Zhu, AU - Durland,Ross H, AU - Katz,Jacqueline M, AU - Sambhara,Suryaprakash, Y1 - 2007/05/09/ PY - 2007/5/15/pubmed PY - 2007/11/6/medline PY - 2007/5/15/entrez SP - 926 EP - 8 JF - Clinical and vaccine immunology : CVI JO - Clin Vaccine Immunol VL - 14 IS - 7 N2 - In the event of another influenza virus pandemic, strategies for effective mass vaccination will urgently be needed. We used a novel transdermal patch delivery technology, known as the PassPort system, to vaccinate mice with recombinant H5 hemagglutinin with or without immunomodulators. This needle-free form of vaccine delivery induced robust serum antibody responses that were augmented by different immunomodulators that stimulated the innate immune system and protected mice against lethal challenge with a highly pathogenic avian H5N1 influenza virus. SN - 1556-6811 UR - https://www.unboundmedicine.com/medline/citation/17494637/Needle_free_skin_patch_delivery_of_a_vaccine_for_a_potentially_pandemic_influenza_virus_provides_protection_against_lethal_challenge_in_mice_ L2 - http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=17494637 DB - PRIME DP - Unbound Medicine ER -