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Migraine aura.

Abstract

Recurrent episodes of transient focal neurologic symptoms, known as aura, occur in association with migraine headache in about 11.9 million people in the United States. At present, the International Headache Society has recognized 3 "typical" auras: visual, sensory, and language. Increasing evidence from investigations in human subjects suggests that typical auras may be the clinical manifestation of a cortical spreading depression (CSD)-like phenomenon. Other studies have shown altered reactivity and processing within the cortices of migraineurs who experience an aura, which might render them more vulnerable to CSD-like events. Recent investigations also support the hypothesis that events intrinsic to the cerebral cortex are capable of activating trigeminal nociceptive neurons and of affecting the caliber of vascular structures innervated by them. A better understanding of the mechanisms underlying the aura may potentially lead to more effective therapies, which will aim at preventing migraine headaches before they start.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. cutrer.michael@mayo.edu

    Source

    The neurologist 13:3 2007 May pg 118-25

    MeSH

    Humans
    Migraine with Aura

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    17495755

    Citation

    Cutrer, F Michael, and Karina Huerter. "Migraine Aura." The Neurologist, vol. 13, no. 3, 2007, pp. 118-25.
    Cutrer FM, Huerter K. Migraine aura. Neurologist. 2007;13(3):118-25.
    Cutrer, F. M., & Huerter, K. (2007). Migraine aura. The Neurologist, 13(3), pp. 118-25.
    Cutrer FM, Huerter K. Migraine Aura. Neurologist. 2007;13(3):118-25. PubMed PMID: 17495755.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Migraine aura. AU - Cutrer,F Michael, AU - Huerter,Karina, PY - 2007/5/15/pubmed PY - 2007/7/19/medline PY - 2007/5/15/entrez SP - 118 EP - 25 JF - The neurologist JO - Neurologist VL - 13 IS - 3 N2 - Recurrent episodes of transient focal neurologic symptoms, known as aura, occur in association with migraine headache in about 11.9 million people in the United States. At present, the International Headache Society has recognized 3 "typical" auras: visual, sensory, and language. Increasing evidence from investigations in human subjects suggests that typical auras may be the clinical manifestation of a cortical spreading depression (CSD)-like phenomenon. Other studies have shown altered reactivity and processing within the cortices of migraineurs who experience an aura, which might render them more vulnerable to CSD-like events. Recent investigations also support the hypothesis that events intrinsic to the cerebral cortex are capable of activating trigeminal nociceptive neurons and of affecting the caliber of vascular structures innervated by them. A better understanding of the mechanisms underlying the aura may potentially lead to more effective therapies, which will aim at preventing migraine headaches before they start. SN - 1074-7931 UR - https://www.unboundmedicine.com/medline/citation/17495755/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=17495755 DB - PRIME DP - Unbound Medicine ER -