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Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity.
Ren Fail. 2007; 29(3):257-63.RF

Abstract

Cisplatin, an effective antineoplastic agent, frequently induces acute renal failure in animals and humans. Hyperbaric oxygen (HBO) has been shown to prevent cisplatin-induced nephrotoxicity in rats. This study investigated the effect of two different HBO regimes on renal functions, oxidative stress, and histopathological changes in rat kidneys after cisplatin treatment. Wistar rats were divided into five groups: control, HBO, cisplatin, cisplatin plus once daily HBO, and cisplatin plus twice daily HBO. Cisplatin was given as a single intraperitoneal dose of 6 mg/kg, and HBO was applied for 60 min at 2.5 atm for six days. HBO alone did not alter any biochemical parameters or histopathological findings compared with the control group. Cisplatin increased serum urea and creatinine levels and caused severe histopathological injury. In addition, cisplatin increased lipid peroxidation and impaired superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in kidney tissue. Once daily HBO after cisplatin treatment slightly reduced serum urea and creatinine levels and attenuated histopathological injury. HBO also reduced lipid peroxidation and increased SOD and GSH-Px activities significantly. Although twice daily HBO was determined to be more effective than once daily HBO on oxidative stress parameters, it increased serum creatinine levels and histopathological injury compared with the cisplatin group. It was concluded that HBO alone does not induce nephrotoxicity and oxidative stress in rat kidneys; once daily HBO may prevent cisplatin-induced nephrotoxicity, an effect that is partially mediated by the modification of oxidant/antioxidant systems in the kidneys; and twice daily HBO potentiates cisplatin nephrotoxicity by a ROS-independent mechanism.

Authors+Show Affiliations

Department of Pediatrics, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Uskudar, Istanbul, Turkey. saydinoz@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17497437

Citation

Aydinoz, Secil, et al. "Effects of Different Doses of Hyperbaric Oxygen On Cisplatin-induced Nephrotoxicity." Renal Failure, vol. 29, no. 3, 2007, pp. 257-63.
Aydinoz S, Uzun G, Cermik H, et al. Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity. Ren Fail. 2007;29(3):257-63.
Aydinoz, S., Uzun, G., Cermik, H., Atasoyu, E. M., Yildiz, S., Karagoz, B., & Evrenkaya, R. (2007). Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity. Renal Failure, 29(3), 257-63.
Aydinoz S, et al. Effects of Different Doses of Hyperbaric Oxygen On Cisplatin-induced Nephrotoxicity. Ren Fail. 2007;29(3):257-63. PubMed PMID: 17497437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity. AU - Aydinoz,Secil, AU - Uzun,Gunalp, AU - Cermik,Hakan, AU - Atasoyu,Enes Murat, AU - Yildiz,Senol, AU - Karagoz,Bulent, AU - Evrenkaya,Rifki, PY - 2007/5/15/pubmed PY - 2008/4/5/medline PY - 2007/5/15/entrez SP - 257 EP - 63 JF - Renal failure JO - Ren Fail VL - 29 IS - 3 N2 - Cisplatin, an effective antineoplastic agent, frequently induces acute renal failure in animals and humans. Hyperbaric oxygen (HBO) has been shown to prevent cisplatin-induced nephrotoxicity in rats. This study investigated the effect of two different HBO regimes on renal functions, oxidative stress, and histopathological changes in rat kidneys after cisplatin treatment. Wistar rats were divided into five groups: control, HBO, cisplatin, cisplatin plus once daily HBO, and cisplatin plus twice daily HBO. Cisplatin was given as a single intraperitoneal dose of 6 mg/kg, and HBO was applied for 60 min at 2.5 atm for six days. HBO alone did not alter any biochemical parameters or histopathological findings compared with the control group. Cisplatin increased serum urea and creatinine levels and caused severe histopathological injury. In addition, cisplatin increased lipid peroxidation and impaired superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in kidney tissue. Once daily HBO after cisplatin treatment slightly reduced serum urea and creatinine levels and attenuated histopathological injury. HBO also reduced lipid peroxidation and increased SOD and GSH-Px activities significantly. Although twice daily HBO was determined to be more effective than once daily HBO on oxidative stress parameters, it increased serum creatinine levels and histopathological injury compared with the cisplatin group. It was concluded that HBO alone does not induce nephrotoxicity and oxidative stress in rat kidneys; once daily HBO may prevent cisplatin-induced nephrotoxicity, an effect that is partially mediated by the modification of oxidant/antioxidant systems in the kidneys; and twice daily HBO potentiates cisplatin nephrotoxicity by a ROS-independent mechanism. SN - 0886-022X UR - https://www.unboundmedicine.com/medline/citation/17497437/Effects_of_different_doses_of_hyperbaric_oxygen_on_cisplatin_induced_nephrotoxicity_ L2 - https://www.tandfonline.com/doi/full/10.1080/08860220601166487 DB - PRIME DP - Unbound Medicine ER -