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The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness.
Acta Paediatr. 2007 Jul; 96(7):1030-5.AP

Abstract

AIM

To analyse the impact of pre- and post-natal smoke exposure on asthma presence, bronchial hyper-responsiveness, airway function and active smoking in early adulthood.

METHODS

We have prospectively studied 101 children hospitalized due to wheezing before the age of 2 years. The cohort was re-investigated at age 17-20 years and tested for airway function and bronchial hyper-responsiveness. Data on maternal smoking during pregnancy were obtained from the Swedish Medical Birth Register.

RESULTS

There was a significant, independent correlation between both pre- and post-natal smoke exposure and asthma at age 17-20 years, OR 3.5 (1.1-11.3) and 3.4 (1.2-10.1), respectively. Maternal smoking during pregnancy was an independent risk factor for current bronchial hyper-responsiveness, OR 6.6 (1.2-35.5). Pre-natal smoke exposure seemed to negatively affect small airway function in early adulthood due to structural changes. Post-natal smoke exposure was independently associated with an increased risk of current smoking, OR 7.4 (1.6-35.2).

CONCLUSION

In subjects hospitalized due to early wheezing, pre- and post-natal smoke exposure increase the risk of asthma in early adulthood. The connection between pre-natal smoke exposure and asthma appears to be mediated via the development of bronchial hyper-responsiveness. Smoke exposure in infancy is associated with an increased risk of active smoking in early adult age, which is in turn linked to current asthma.

Authors+Show Affiliations

Department of Paediatrics, Göteborg University, Queen Silvia Children's Hospital, Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17498194

Citation

Goksör, Emma, et al. "The Impact of Pre- and Post-natal Smoke Exposure On Future Asthma and Bronchial Hyper-responsiveness." Acta Paediatrica (Oslo, Norway : 1992), vol. 96, no. 7, 2007, pp. 1030-5.
Goksör E, Amark M, Alm B, et al. The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness. Acta Paediatr. 2007;96(7):1030-5.
Goksör, E., Amark, M., Alm, B., Gustafsson, P. M., & Wennergren, G. (2007). The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness. Acta Paediatrica (Oslo, Norway : 1992), 96(7), 1030-5.
Goksör E, et al. The Impact of Pre- and Post-natal Smoke Exposure On Future Asthma and Bronchial Hyper-responsiveness. Acta Paediatr. 2007;96(7):1030-5. PubMed PMID: 17498194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of pre- and post-natal smoke exposure on future asthma and bronchial hyper-responsiveness. AU - Goksör,Emma, AU - Amark,Mainor, AU - Alm,Bernt, AU - Gustafsson,Per M, AU - Wennergren,Göran, Y1 - 2007/05/10/ PY - 2007/5/15/pubmed PY - 2007/8/23/medline PY - 2007/5/15/entrez SP - 1030 EP - 5 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 96 IS - 7 N2 - AIM: To analyse the impact of pre- and post-natal smoke exposure on asthma presence, bronchial hyper-responsiveness, airway function and active smoking in early adulthood. METHODS: We have prospectively studied 101 children hospitalized due to wheezing before the age of 2 years. The cohort was re-investigated at age 17-20 years and tested for airway function and bronchial hyper-responsiveness. Data on maternal smoking during pregnancy were obtained from the Swedish Medical Birth Register. RESULTS: There was a significant, independent correlation between both pre- and post-natal smoke exposure and asthma at age 17-20 years, OR 3.5 (1.1-11.3) and 3.4 (1.2-10.1), respectively. Maternal smoking during pregnancy was an independent risk factor for current bronchial hyper-responsiveness, OR 6.6 (1.2-35.5). Pre-natal smoke exposure seemed to negatively affect small airway function in early adulthood due to structural changes. Post-natal smoke exposure was independently associated with an increased risk of current smoking, OR 7.4 (1.6-35.2). CONCLUSION: In subjects hospitalized due to early wheezing, pre- and post-natal smoke exposure increase the risk of asthma in early adulthood. The connection between pre-natal smoke exposure and asthma appears to be mediated via the development of bronchial hyper-responsiveness. Smoke exposure in infancy is associated with an increased risk of active smoking in early adult age, which is in turn linked to current asthma. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/17498194/The_impact_of_pre__and_post_natal_smoke_exposure_on_future_asthma_and_bronchial_hyper_responsiveness_ L2 - https://doi.org/10.1111/j.1651-2227.2007.00296.x DB - PRIME DP - Unbound Medicine ER -