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What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific?
J Gastroenterol Hepatol. 2007 Jun; 22(6):794-800.JG

Abstract

The risk factors and settings for non-alcoholic fatty liver disease (NAFLD) in Asians are reviewed comprehensively. Based particularly on large community-based studies using ultrasonography, case-control series and prospective longitudinal studies, the prevalence of NAFLD in Asia is between 12% and 24%, depending on age, gender, locality and ethnicity. Further, the prevalence in China and Japan has nearly doubled in the last 10-15 years. A detailed analysis of these data shows that NAFLD risk factors for Asians resemble those in the West for age at presentation, prevalence of type 2 diabetes mellitus (T2DM) and hyperlipidemia. The apparent differences in prevalence of central obesity and overall obesity are related to criteria used to define waist circumference and body mass index (BMI), respectively. The strongest associations are with components of the metabolic syndrome, particularly the combined presence of central obesity and obesity. Non-alcoholic fatty liver disease appears to be associated with long-standing insulin resistance and likely represents the hepatic manifestation of metabolic syndrome. Not surprisingly therefore, Asians with NAFLD are at high risk of developing diabetes and cardiovascular disease. Conversely, metabolic syndrome may precede the diagnosis of NAFLD. The increasing prevalence of obesity, coupled with T2DM, dyslipidemia, hypertension and ultimately metabolic syndrome puts more than half the world's population at risk of developing NAFLD/non-alcoholic steatohepatitis/cirrhosis in the coming decades. Public health initiatives are clearly imperative to halt or reverse the global 'diabesity' pandemic, the underlying basis of NAFLD and metabolic syndrome. In addition, a perspective of NAFLD beyond its hepatic consequences is now warranted; this needs to be considered in relation to management guidelines for affected individuals.

Authors+Show Affiliations

Center for Fatty Liver Disease, Shanghai First People's Hospital, Jiaotong University, Shanghai, China. fanjg@citiz.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17498218

Citation

Fan, Jian-Gao, et al. "What Are the Risk Factors and Settings for Non-alcoholic Fatty Liver Disease in Asia-Pacific?" Journal of Gastroenterology and Hepatology, vol. 22, no. 6, 2007, pp. 794-800.
Fan JG, Saibara T, Chitturi S, et al. What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific? J Gastroenterol Hepatol. 2007;22(6):794-800.
Fan, J. G., Saibara, T., Chitturi, S., Kim, B. I., Sung, J. J., & Chutaputti, A. (2007). What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific? Journal of Gastroenterology and Hepatology, 22(6), 794-800.
Fan JG, et al. What Are the Risk Factors and Settings for Non-alcoholic Fatty Liver Disease in Asia-Pacific. J Gastroenterol Hepatol. 2007;22(6):794-800. PubMed PMID: 17498218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific? AU - Fan,Jian-Gao, AU - Saibara,Toshiji, AU - Chitturi,Shivakumar, AU - Kim,Byong Ik, AU - Sung,Joseph J Y, AU - Chutaputti,A, AU - ,, Y1 - 2007/05/13/ PY - 2007/5/15/pubmed PY - 2007/9/28/medline PY - 2007/5/15/entrez SP - 794 EP - 800 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 22 IS - 6 N2 - The risk factors and settings for non-alcoholic fatty liver disease (NAFLD) in Asians are reviewed comprehensively. Based particularly on large community-based studies using ultrasonography, case-control series and prospective longitudinal studies, the prevalence of NAFLD in Asia is between 12% and 24%, depending on age, gender, locality and ethnicity. Further, the prevalence in China and Japan has nearly doubled in the last 10-15 years. A detailed analysis of these data shows that NAFLD risk factors for Asians resemble those in the West for age at presentation, prevalence of type 2 diabetes mellitus (T2DM) and hyperlipidemia. The apparent differences in prevalence of central obesity and overall obesity are related to criteria used to define waist circumference and body mass index (BMI), respectively. The strongest associations are with components of the metabolic syndrome, particularly the combined presence of central obesity and obesity. Non-alcoholic fatty liver disease appears to be associated with long-standing insulin resistance and likely represents the hepatic manifestation of metabolic syndrome. Not surprisingly therefore, Asians with NAFLD are at high risk of developing diabetes and cardiovascular disease. Conversely, metabolic syndrome may precede the diagnosis of NAFLD. The increasing prevalence of obesity, coupled with T2DM, dyslipidemia, hypertension and ultimately metabolic syndrome puts more than half the world's population at risk of developing NAFLD/non-alcoholic steatohepatitis/cirrhosis in the coming decades. Public health initiatives are clearly imperative to halt or reverse the global 'diabesity' pandemic, the underlying basis of NAFLD and metabolic syndrome. In addition, a perspective of NAFLD beyond its hepatic consequences is now warranted; this needs to be considered in relation to management guidelines for affected individuals. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17498218/What_are_the_risk_factors_and_settings_for_non_alcoholic_fatty_liver_disease_in_Asia_Pacific L2 - https://doi.org/10.1111/j.1440-1746.2007.04952.x DB - PRIME DP - Unbound Medicine ER -