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The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.
Neurosci Lett 2007; 419(3):195-8NL

Abstract

The cell division cycle 2 (CDC2) gene is a candidate susceptibility gene for Alzheimer's disease (AD). We investigated the CDC2 genotype, and allele and haplotype frequencies in AD patients and matched controls, distinguishing between apolipoprotein E (APOE) epsilon4 allele carriers and non-carriers. APOE epsilon4 is an established predictor of AD risk. APOE and CDC2 genotypes were examined in 109 sporadic AD patients and in 110 healthy age- and sex-matched controls from Sicily. The epsilon4 allele of APOE was predictive of AD risk in our study group (odds ratio: 5.37, 95% CI 2.77-10.41; P<0.0001). Genotype and allele frequencies of the three tested CDC2 polymorphisms (Ex6+7I/D, Ex7-15 G>A, Ex7-14 T>A) were not significantly different between AD patients and controls. However, a significant different distribution of a specific CDC2 haplotype (I-G-T) was found between AD patients and controls when analyzing APOE epsilon4-positive subjects (P=0.0288). Moreover, the combined presence of the I-G-T haplotype and the epsilon4 allele almost doubled the risk of AD (odds ratio: 10.09, 95% CI 3.88-26.25; P<0.0001) compared to carriers of epsilon4 alone. This study suggests that the I-G-T haplotype of the CDC2 gene increases the risk of AD in APOE epsilon4 carriers.

Authors+Show Affiliations

IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Enna, Italy. pbosco@oasi.en.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17498878

Citation

Bosco, Paolo, et al. "The CDC2 I-G-T Haplotype Associated With the APOE Epsilon4 Allele Increases the Risk of Sporadic Alzheimer's Disease in Sicily." Neuroscience Letters, vol. 419, no. 3, 2007, pp. 195-8.
Bosco P, Caraci F, Copani A, et al. The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neurosci Lett. 2007;419(3):195-8.
Bosco, P., Caraci, F., Copani, A., Spada, R. S., Sortino, M. A., Salluzzo, R., ... Ferri, R. (2007). The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neuroscience Letters, 419(3), pp. 195-8.
Bosco P, et al. The CDC2 I-G-T Haplotype Associated With the APOE Epsilon4 Allele Increases the Risk of Sporadic Alzheimer's Disease in Sicily. Neurosci Lett. 2007 Jun 4;419(3):195-8. PubMed PMID: 17498878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. AU - Bosco,Paolo, AU - Caraci,Filippo, AU - Copani,Agata, AU - Spada,Rosario S, AU - Sortino,Maria Angela, AU - Salluzzo,Roberto, AU - Salemi,Michele, AU - Nicoletti,Ferdinando, AU - Ferri,Raffaele, Y1 - 2007/04/08/ PY - 2007/01/25/received PY - 2007/04/03/revised PY - 2007/04/03/accepted PY - 2007/5/15/pubmed PY - 2007/9/29/medline PY - 2007/5/15/entrez SP - 195 EP - 8 JF - Neuroscience letters JO - Neurosci. Lett. VL - 419 IS - 3 N2 - The cell division cycle 2 (CDC2) gene is a candidate susceptibility gene for Alzheimer's disease (AD). We investigated the CDC2 genotype, and allele and haplotype frequencies in AD patients and matched controls, distinguishing between apolipoprotein E (APOE) epsilon4 allele carriers and non-carriers. APOE epsilon4 is an established predictor of AD risk. APOE and CDC2 genotypes were examined in 109 sporadic AD patients and in 110 healthy age- and sex-matched controls from Sicily. The epsilon4 allele of APOE was predictive of AD risk in our study group (odds ratio: 5.37, 95% CI 2.77-10.41; P<0.0001). Genotype and allele frequencies of the three tested CDC2 polymorphisms (Ex6+7I/D, Ex7-15 G>A, Ex7-14 T>A) were not significantly different between AD patients and controls. However, a significant different distribution of a specific CDC2 haplotype (I-G-T) was found between AD patients and controls when analyzing APOE epsilon4-positive subjects (P=0.0288). Moreover, the combined presence of the I-G-T haplotype and the epsilon4 allele almost doubled the risk of AD (odds ratio: 10.09, 95% CI 3.88-26.25; P<0.0001) compared to carriers of epsilon4 alone. This study suggests that the I-G-T haplotype of the CDC2 gene increases the risk of AD in APOE epsilon4 carriers. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17498878/The_CDC2_I_G_T_haplotype_associated_with_the_APOE_epsilon4_allele_increases_the_risk_of_sporadic_Alzheimer's_disease_in_Sicily_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)00424-7 DB - PRIME DP - Unbound Medicine ER -