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The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.
Neurosci Lett 2007; 419(3):195-8NL

Abstract

The cell division cycle 2 (CDC2) gene is a candidate susceptibility gene for Alzheimer's disease (AD). We investigated the CDC2 genotype, and allele and haplotype frequencies in AD patients and matched controls, distinguishing between apolipoprotein E (APOE) epsilon4 allele carriers and non-carriers. APOE epsilon4 is an established predictor of AD risk. APOE and CDC2 genotypes were examined in 109 sporadic AD patients and in 110 healthy age- and sex-matched controls from Sicily. The epsilon4 allele of APOE was predictive of AD risk in our study group (odds ratio: 5.37, 95% CI 2.77-10.41; P<0.0001). Genotype and allele frequencies of the three tested CDC2 polymorphisms (Ex6+7I/D, Ex7-15 G>A, Ex7-14 T>A) were not significantly different between AD patients and controls. However, a significant different distribution of a specific CDC2 haplotype (I-G-T) was found between AD patients and controls when analyzing APOE epsilon4-positive subjects (P=0.0288). Moreover, the combined presence of the I-G-T haplotype and the epsilon4 allele almost doubled the risk of AD (odds ratio: 10.09, 95% CI 3.88-26.25; P<0.0001) compared to carriers of epsilon4 alone. This study suggests that the I-G-T haplotype of the CDC2 gene increases the risk of AD in APOE epsilon4 carriers.

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    • Authors+Show Affiliations

    Bosco P
    IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Enna, Italy. pbosco@oasi.en.it
    Caraci F
    No affiliation info available
    Copani A
    No affiliation info available
    Spada RS
    No affiliation info available
    Sortino MA
    No affiliation info available
    Salluzzo R
    No affiliation info available
    Salemi M
    No affiliation info available
    Nicoletti F
    No affiliation info available
    Ferri R
    No affiliation info available

    MeSH

    Alzheimer DiseaseApolipoprotein E4Cell Cycle ProteinsFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMalePolymerase Chain ReactionPolymorphism, GeneticRisk FactorsSicily

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17498878

    Citation

    Bosco, Paolo, et al. "The CDC2 I-G-T Haplotype Associated With the APOE Epsilon4 Allele Increases the Risk of Sporadic Alzheimer's Disease in Sicily." Neuroscience Letters, vol. 419, no. 3, 2007, pp. 195-8.
    Bosco P, Caraci F, Copani A, et al. The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neurosci Lett. 2007;419(3):195-8.
    Bosco, P., Caraci, F., Copani, A., Spada, R. S., Sortino, M. A., Salluzzo, R., ... Ferri, R. (2007). The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. Neuroscience Letters, 419(3), pp. 195-8.
    Bosco P, et al. The CDC2 I-G-T Haplotype Associated With the APOE Epsilon4 Allele Increases the Risk of Sporadic Alzheimer's Disease in Sicily. Neurosci Lett. 2007 Jun 4;419(3):195-8. PubMed PMID: 17498878.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily. AU - Bosco,Paolo, AU - Caraci,Filippo, AU - Copani,Agata, AU - Spada,Rosario S, AU - Sortino,Maria Angela, AU - Salluzzo,Roberto, AU - Salemi,Michele, AU - Nicoletti,Ferdinando, AU - Ferri,Raffaele, Y1 - 2007/04/08/ PY - 2007/01/25/received PY - 2007/04/03/revised PY - 2007/04/03/accepted PY - 2007/5/15/pubmed PY - 2007/9/29/medline PY - 2007/5/15/entrez SP - 195 EP - 8 JF - Neuroscience letters JO - Neurosci. Lett. VL - 419 IS - 3 N2 - The cell division cycle 2 (CDC2) gene is a candidate susceptibility gene for Alzheimer's disease (AD). We investigated the CDC2 genotype, and allele and haplotype frequencies in AD patients and matched controls, distinguishing between apolipoprotein E (APOE) epsilon4 allele carriers and non-carriers. APOE epsilon4 is an established predictor of AD risk. APOE and CDC2 genotypes were examined in 109 sporadic AD patients and in 110 healthy age- and sex-matched controls from Sicily. The epsilon4 allele of APOE was predictive of AD risk in our study group (odds ratio: 5.37, 95% CI 2.77-10.41; P<0.0001). Genotype and allele frequencies of the three tested CDC2 polymorphisms (Ex6+7I/D, Ex7-15 G>A, Ex7-14 T>A) were not significantly different between AD patients and controls. However, a significant different distribution of a specific CDC2 haplotype (I-G-T) was found between AD patients and controls when analyzing APOE epsilon4-positive subjects (P=0.0288). Moreover, the combined presence of the I-G-T haplotype and the epsilon4 allele almost doubled the risk of AD (odds ratio: 10.09, 95% CI 3.88-26.25; P<0.0001) compared to carriers of epsilon4 alone. This study suggests that the I-G-T haplotype of the CDC2 gene increases the risk of AD in APOE epsilon4 carriers. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17498878/The_CDC2_I_G_T_haplotype_associated_with_the_APOE_epsilon4_allele_increases_the_risk_of_sporadic_Alzheimer's_disease_in_Sicily_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)00424-7 DB - PRIME DP - Unbound Medicine ER -