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Antimicrobial activity of Diospyros anisandra.
Fitoterapia. 2007 Jul; 78(5):370-2.F

Abstract

Leaves, root and stem bark of Diospyros anisandra were screened against two strains of Mycobacterium tuberculosis, one resistant and one susceptible to antibiotics, using the microplate Alamar blue assay test. The lypophylic fractions of the root and bark showed significant inhibitory activity against both strains, with the hexane fraction of the bark showing the strongest activity (MIC 6.25 microg/ml) against the resistant strain and a significant antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus niger, and Colletotrichum gloeosporioides. The bioassay-guided purification of the bioactive hexane fraction resulted in the isolation and identification of the naphthoquinone plumbagin as one of the metabolites responsible for the biological activity.

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Authors+Show Affiliations

Borges-Argáez R
Centro de Investigación Científica de Yucatán, Calle 43 No 130 Chuburná, Mérida, Yucatán, Mexico. ai800102@sohu.com
Canche-Chay CI
No affiliation info available
Peña-Rodríguez LM
No affiliation info available
Said-Fernández S
No affiliation info available
Molina-Salinas GM
No affiliation info available

MeSH

Anti-Bacterial AgentsDiospyrosGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsMycobacterium tuberculosisPhytotherapyPlant BarkPlant ExtractsPlant LeavesPlant Roots

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17498888

Citation

Borges-Argáez, Rocio, et al. "Antimicrobial Activity of Diospyros Anisandra." Fitoterapia, vol. 78, no. 5, 2007, pp. 370-2.
Borges-Argáez R, Canche-Chay CI, Peña-Rodríguez LM, et al. Antimicrobial activity of Diospyros anisandra. Fitoterapia. 2007;78(5):370-2.
Borges-Argáez, R., Canche-Chay, C. I., Peña-Rodríguez, L. M., Said-Fernández, S., & Molina-Salinas, G. M. (2007). Antimicrobial activity of Diospyros anisandra. Fitoterapia, 78(5), 370-2.
Borges-Argáez R, et al. Antimicrobial Activity of Diospyros Anisandra. Fitoterapia. 2007;78(5):370-2. PubMed PMID: 17498888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity of Diospyros anisandra. AU - Borges-Argáez,Rocio, AU - Canche-Chay,Cristina Isabel, AU - Peña-Rodríguez,Luis M, AU - Said-Fernández,Salvador, AU - Molina-Salinas,Gloria María, Y1 - 2007/04/11/ PY - 2006/06/05/received PY - 2007/03/02/accepted PY - 2007/5/15/pubmed PY - 2007/9/7/medline PY - 2007/5/15/entrez SP - 370 EP - 2 JF - Fitoterapia JO - Fitoterapia VL - 78 IS - 5 N2 - Leaves, root and stem bark of Diospyros anisandra were screened against two strains of Mycobacterium tuberculosis, one resistant and one susceptible to antibiotics, using the microplate Alamar blue assay test. The lypophylic fractions of the root and bark showed significant inhibitory activity against both strains, with the hexane fraction of the bark showing the strongest activity (MIC 6.25 microg/ml) against the resistant strain and a significant antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus niger, and Colletotrichum gloeosporioides. The bioassay-guided purification of the bioactive hexane fraction resulted in the isolation and identification of the naphthoquinone plumbagin as one of the metabolites responsible for the biological activity. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/17498888/Antimicrobial_activity_of_Diospyros_anisandra_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(07)00088-3 DB - PRIME DP - Unbound Medicine ER -