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Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice.
Int Immunopharmacol. 2007 Jul; 7(7):963-72.II

Abstract

There have been a number of reports showing that the crude beta-glucan fraction prepared from various kinds of Basidiomycetes mushrooms acts as anti-cancer and anti-allergic reagent through stimulation of IFN-gamma production. It has been reported, however, that the exposure of the airway to beta-(1,3) d-glucan, contained in house dust, indoor moulds and some bacteria, potentiates the airway allergic response. It seems likely that the discrepant effects on immune function may be related to such factors as differences of the administration route, average molecular weight and water solubility. We isolated a new low-molecular-weight (about 100 kDa) beta-glucan from Aureobasidium pullulans 1A1 strain of black yeast, and found that it had low viscosity and was water-soluble. In this study, we examined the effects of water-soluble low-molecular-weight beta-(1-->3) and 50-80% branched beta-(1-->6) glucan (LMW-beta-Glucan) isolated from A. pullulans on the ova-albumin (OVA)-treated allergic reaction in mice. Feeding standard laboratory diets containing 0.5 and 1% LMW-beta-Glucan significantly inhibited the OVA-specific IgE elevation compared to that in OVA-sensitized mice fed standard laboratory diet alone (control). Furthermore, feeding standard laboratory diets containing 0.5 and 1% LMW-beta-Glucan inhibited the reduction of IL-12 and IFN-gamma production from splenocytes and the reduction of CD8- and IFN-gamma-positive cell number in the small intestine of the OVA-sensitized mice. These findings suggest that anti-food allergic action of LMW-beta-Glucan may be due to the inducing IFN-gamma production in the small intestine and splenocytes.

Authors+Show Affiliations

Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-City, Ehime 791-0295, Japan. yokim@m.ehime-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17499199

Citation

Kimura, Yoshiyuki, et al. "Inhibitory Effects of Water-soluble Low-molecular-weight Beta-(1,3-1,6) D-glucan Purified From Aureobasidium Pullulans GM-NH-1A1 Strain On Food Allergic Reactions in Mice." International Immunopharmacology, vol. 7, no. 7, 2007, pp. 963-72.
Kimura Y, Sumiyoshi M, Suzuki T, et al. Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice. Int Immunopharmacol. 2007;7(7):963-72.
Kimura, Y., Sumiyoshi, M., Suzuki, T., Suzuki, T., & Sakanaka, M. (2007). Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice. International Immunopharmacology, 7(7), 963-72.
Kimura Y, et al. Inhibitory Effects of Water-soluble Low-molecular-weight Beta-(1,3-1,6) D-glucan Purified From Aureobasidium Pullulans GM-NH-1A1 Strain On Food Allergic Reactions in Mice. Int Immunopharmacol. 2007;7(7):963-72. PubMed PMID: 17499199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of water-soluble low-molecular-weight beta-(1,3-1,6) d-glucan purified from Aureobasidium pullulans GM-NH-1A1 strain on food allergic reactions in mice. AU - Kimura,Yoshiyuki, AU - Sumiyoshi,Maho, AU - Suzuki,Takahiro, AU - Suzuki,Toshio, AU - Sakanaka,Masahiro, Y1 - 2007/04/11/ PY - 2006/11/29/received PY - 2007/03/02/revised PY - 2007/03/11/accepted PY - 2007/5/15/pubmed PY - 2007/10/5/medline PY - 2007/5/15/entrez SP - 963 EP - 72 JF - International immunopharmacology JO - Int Immunopharmacol VL - 7 IS - 7 N2 - There have been a number of reports showing that the crude beta-glucan fraction prepared from various kinds of Basidiomycetes mushrooms acts as anti-cancer and anti-allergic reagent through stimulation of IFN-gamma production. It has been reported, however, that the exposure of the airway to beta-(1,3) d-glucan, contained in house dust, indoor moulds and some bacteria, potentiates the airway allergic response. It seems likely that the discrepant effects on immune function may be related to such factors as differences of the administration route, average molecular weight and water solubility. We isolated a new low-molecular-weight (about 100 kDa) beta-glucan from Aureobasidium pullulans 1A1 strain of black yeast, and found that it had low viscosity and was water-soluble. In this study, we examined the effects of water-soluble low-molecular-weight beta-(1-->3) and 50-80% branched beta-(1-->6) glucan (LMW-beta-Glucan) isolated from A. pullulans on the ova-albumin (OVA)-treated allergic reaction in mice. Feeding standard laboratory diets containing 0.5 and 1% LMW-beta-Glucan significantly inhibited the OVA-specific IgE elevation compared to that in OVA-sensitized mice fed standard laboratory diet alone (control). Furthermore, feeding standard laboratory diets containing 0.5 and 1% LMW-beta-Glucan inhibited the reduction of IL-12 and IFN-gamma production from splenocytes and the reduction of CD8- and IFN-gamma-positive cell number in the small intestine of the OVA-sensitized mice. These findings suggest that anti-food allergic action of LMW-beta-Glucan may be due to the inducing IFN-gamma production in the small intestine and splenocytes. SN - 1567-5769 UR - https://www.unboundmedicine.com/medline/citation/17499199/Inhibitory_effects_of_water_soluble_low_molecular_weight_beta__13_16__d_glucan_purified_from_Aureobasidium_pullulans_GM_NH_1A1_strain_on_food_allergic_reactions_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(07)00083-5 DB - PRIME DP - Unbound Medicine ER -