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The effects of long-term administration of oral desmopressin on the baseline secretion of antidiuretic hormone and serum sodium concentration for the treatment of nocturia: a circadian study.
J Urol. 2007 Jul; 178(1):200-3.JU

Abstract

PURPOSE

We assessed the effects of long-term oral desmopressin on serum sodium and baseline antidiuretic hormone secretion in elderly patients with nocturia.

MATERIALS AND METHODS

A total of 15 elderly male patients with severe nocturia (greater than 3 voids nightly) who did not show hyponatremia within 7 days of administration of 0.2 mg desmopressin were enrolled in this study. Desmopressin (0.2 mg) was administered orally nightly for 1 year. Before and 1 month after the 1-year medication 24-hour circadian studies were performed to monitor changes in antidiuretic hormone. Every 3 months during the 1-year medication serum changes and timed urine chemistry were monitored.

RESULTS

Desmopressin significantly decreased nocturnal urine output and the number of nocturia episodes (p<0.01). Compared to before treatment desmopressin gradually decreased serum sodium and induced statistically but not clinically significant hyponatremia after 6 months of treatment. After discontinuing desmopressin serum sodium returned to the normal range in all patients. There were no significant differences when baseline and posttreatment endogenous antidiuretic hormone were compared. No serious systemic complications were found during medication.

CONCLUSIONS

Long-term desmopressin administration gradually decreased the serum concentration and induced significant hyponatremia from 6 months in patients who did not show initial hyponatremia. Long-term administration of desmopressin for 1 year in elderly patients did not affect baseline antidiuretic hormone secretion. For long-term desmopressin administration serum sodium should be assessed regularly, at least every 6 months.

Authors+Show Affiliations

Department of Urology, Korea University College of Medicine, and Korea University Guro Hospital, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17499799

Citation

Bae, J H., et al. "The Effects of Long-term Administration of Oral Desmopressin On the Baseline Secretion of Antidiuretic Hormone and Serum Sodium Concentration for the Treatment of Nocturia: a Circadian Study." The Journal of Urology, vol. 178, no. 1, 2007, pp. 200-3.
Bae JH, Oh MM, Shim KS, et al. The effects of long-term administration of oral desmopressin on the baseline secretion of antidiuretic hormone and serum sodium concentration for the treatment of nocturia: a circadian study. J Urol. 2007;178(1):200-3.
Bae, J. H., Oh, M. M., Shim, K. S., Cheon, J., Lee, J. G., Kim, J. J., & Moon, D. G. (2007). The effects of long-term administration of oral desmopressin on the baseline secretion of antidiuretic hormone and serum sodium concentration for the treatment of nocturia: a circadian study. The Journal of Urology, 178(1), 200-3.
Bae JH, et al. The Effects of Long-term Administration of Oral Desmopressin On the Baseline Secretion of Antidiuretic Hormone and Serum Sodium Concentration for the Treatment of Nocturia: a Circadian Study. J Urol. 2007;178(1):200-3. PubMed PMID: 17499799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of long-term administration of oral desmopressin on the baseline secretion of antidiuretic hormone and serum sodium concentration for the treatment of nocturia: a circadian study. AU - Bae,J H, AU - Oh,M M, AU - Shim,K S, AU - Cheon,J, AU - Lee,J G, AU - Kim,J J, AU - Moon,D G, Y1 - 2007/05/17/ PY - 2006/11/26/received PY - 2007/5/15/pubmed PY - 2007/7/18/medline PY - 2007/5/15/entrez SP - 200 EP - 3 JF - The Journal of urology JO - J Urol VL - 178 IS - 1 N2 - PURPOSE: We assessed the effects of long-term oral desmopressin on serum sodium and baseline antidiuretic hormone secretion in elderly patients with nocturia. MATERIALS AND METHODS: A total of 15 elderly male patients with severe nocturia (greater than 3 voids nightly) who did not show hyponatremia within 7 days of administration of 0.2 mg desmopressin were enrolled in this study. Desmopressin (0.2 mg) was administered orally nightly for 1 year. Before and 1 month after the 1-year medication 24-hour circadian studies were performed to monitor changes in antidiuretic hormone. Every 3 months during the 1-year medication serum changes and timed urine chemistry were monitored. RESULTS: Desmopressin significantly decreased nocturnal urine output and the number of nocturia episodes (p<0.01). Compared to before treatment desmopressin gradually decreased serum sodium and induced statistically but not clinically significant hyponatremia after 6 months of treatment. After discontinuing desmopressin serum sodium returned to the normal range in all patients. There were no significant differences when baseline and posttreatment endogenous antidiuretic hormone were compared. No serious systemic complications were found during medication. CONCLUSIONS: Long-term desmopressin administration gradually decreased the serum concentration and induced significant hyponatremia from 6 months in patients who did not show initial hyponatremia. Long-term administration of desmopressin for 1 year in elderly patients did not affect baseline antidiuretic hormone secretion. For long-term desmopressin administration serum sodium should be assessed regularly, at least every 6 months. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17499799/The_effects_of_long_term_administration_of_oral_desmopressin_on_the_baseline_secretion_of_antidiuretic_hormone_and_serum_sodium_concentration_for_the_treatment_of_nocturia:_a_circadian_study_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.03.042?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -