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Characterization of Japanese-American men with a single neocortical AD lesion type.
Neurobiol Aging. 2008 Oct; 29(10):1448-55.NA

Abstract

Neocortical neuritic plaques (NP) and neurofibrillary tangles (NFT) are hallmarks of Alzheimer's disease (AD) and usually, both are present. The Honolulu-Asia Aging Study autopsy series includes a significant number of individuals with only one neocortical AD lesion type. These could represent an early phase of the AD process. If so, such individuals would be expected to share other clinical and pathological features of AD. We compared frequency of apolipoprotein epsilon E4 (APOE4) allele, average Braak stage, and burden of cerebral amyloid angiopathy (CAA) among the two single lesion type groups, a group without AD lesions, and groups with high and low frequencies of both AD lesions. Single AD lesion groups shared only the characteristics associated with their unique lesion type with the combined AD lesion group and did not have higher prevalence of dementia than the no AD lesion group. Only the NP+NFT group showed a "dose-response" relationship with greater probability of dementia with higher neocortical frequencies of either AD lesion. The single neocortical AD lesion groups do not appear to represent early AD.

Authors+Show Affiliations

Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA. hpetrovitch@phrihawaii.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17499884

Citation

Petrovitch, Helen, et al. "Characterization of Japanese-American Men With a Single Neocortical AD Lesion Type." Neurobiology of Aging, vol. 29, no. 10, 2008, pp. 1448-55.
Petrovitch H, Ross GW, He Q, et al. Characterization of Japanese-American men with a single neocortical AD lesion type. Neurobiol Aging. 2008;29(10):1448-55.
Petrovitch, H., Ross, G. W., He, Q., Uyehara-Lock, J., Markesbery, W., Davis, D., Nelson, J., Masaki, K., Launer, L., & White, L. R. (2008). Characterization of Japanese-American men with a single neocortical AD lesion type. Neurobiology of Aging, 29(10), 1448-55.
Petrovitch H, et al. Characterization of Japanese-American Men With a Single Neocortical AD Lesion Type. Neurobiol Aging. 2008;29(10):1448-55. PubMed PMID: 17499884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of Japanese-American men with a single neocortical AD lesion type. AU - Petrovitch,Helen, AU - Ross,G Webster, AU - He,Qimei, AU - Uyehara-Lock,Jane, AU - Markesbery,William, AU - Davis,Daron, AU - Nelson,James, AU - Masaki,Kamal, AU - Launer,Lenore, AU - White,Lon R, Y1 - 2007/05/17/ PY - 2006/04/20/received PY - 2007/03/22/revised PY - 2007/03/30/accepted PY - 2007/5/15/pubmed PY - 2008/11/18/medline PY - 2007/5/15/entrez SP - 1448 EP - 55 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 29 IS - 10 N2 - Neocortical neuritic plaques (NP) and neurofibrillary tangles (NFT) are hallmarks of Alzheimer's disease (AD) and usually, both are present. The Honolulu-Asia Aging Study autopsy series includes a significant number of individuals with only one neocortical AD lesion type. These could represent an early phase of the AD process. If so, such individuals would be expected to share other clinical and pathological features of AD. We compared frequency of apolipoprotein epsilon E4 (APOE4) allele, average Braak stage, and burden of cerebral amyloid angiopathy (CAA) among the two single lesion type groups, a group without AD lesions, and groups with high and low frequencies of both AD lesions. Single AD lesion groups shared only the characteristics associated with their unique lesion type with the combined AD lesion group and did not have higher prevalence of dementia than the no AD lesion group. Only the NP+NFT group showed a "dose-response" relationship with greater probability of dementia with higher neocortical frequencies of either AD lesion. The single neocortical AD lesion groups do not appear to represent early AD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/17499884/Characterization_of_Japanese_American_men_with_a_single_neocortical_AD_lesion_type_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(07)00136-4 DB - PRIME DP - Unbound Medicine ER -