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A randomized trial on the efficacy of a 2-month tube feeding regimen in anorexia nervosa: A 1-year follow-up study.
Clin Nutr 2007; 26(4):421-9CN

Abstract

BACKGROUND & AIMS

Despite the high mortality rate in malnourished anorexia nervosa (AN) patients, very few trials have prospectively studied the efficacy of tube feeding.

METHODS

This open prospective study was conducted in malnourished AN patients, who were randomized in tube feeding (n=41) or control (n=40) groups during a 2-month period. Thereafter, body weight, body mass gain, energy intake, eating behavior and relapse rates were compared during a 1-year follow-up, using paired Student t-test and ANOVA.

RESULTS

At the end of the 2-months period, weight gain was 39% higher in the tube feeding group than in the control group (194+/-14 vs 126+/-19g/day; P<0.01). The fat-free mass gain was greater in the tube-feeding group: 109+/-14 vs 61+/-17g/day (P<0.01). Energy intake was higher in the tube feeding group than in the control group (P<0.05), as well as the decrease in bingeing episodes (P<0.01). Most patients thought that CEN improved their eating disorder. After discharge, the relapse-free period was longer in the CEN group than in the control one: 34.3+/-8.2 weeks vs 26.8+/-7.5 weeks (P<0.05).

CONCLUSION

CEN is helpful in malnourished AN patients for weight restoration, without hindrance on the eating behavior therapy nor inducing a more rapid relapse.

Authors+Show Affiliations

Service d'Endocrinologie et Nutrition, CHU Le Bocage, 21079, Dijon, France. daniel.rigaud@chu-dijon.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17499892

Citation

Rigaud, Daniel, et al. "A Randomized Trial On the Efficacy of a 2-month Tube Feeding Regimen in Anorexia Nervosa: a 1-year Follow-up Study." Clinical Nutrition (Edinburgh, Scotland), vol. 26, no. 4, 2007, pp. 421-9.
Rigaud D, Brondel L, Poupard AT, et al. A randomized trial on the efficacy of a 2-month tube feeding regimen in anorexia nervosa: A 1-year follow-up study. Clin Nutr. 2007;26(4):421-9.
Rigaud, D., Brondel, L., Poupard, A. T., Talonneau, I., & Brun, J. M. (2007). A randomized trial on the efficacy of a 2-month tube feeding regimen in anorexia nervosa: A 1-year follow-up study. Clinical Nutrition (Edinburgh, Scotland), 26(4), pp. 421-9.
Rigaud D, et al. A Randomized Trial On the Efficacy of a 2-month Tube Feeding Regimen in Anorexia Nervosa: a 1-year Follow-up Study. Clin Nutr. 2007;26(4):421-9. PubMed PMID: 17499892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized trial on the efficacy of a 2-month tube feeding regimen in anorexia nervosa: A 1-year follow-up study. AU - Rigaud,Daniel, AU - Brondel,Laurent, AU - Poupard,Anne Thérèse, AU - Talonneau,Isabelle, AU - Brun,Jean Marcel, Y1 - 2007/05/17/ PY - 2006/08/30/received PY - 2007/03/28/revised PY - 2007/03/28/accepted PY - 2007/5/15/pubmed PY - 2007/10/24/medline PY - 2007/5/15/entrez SP - 421 EP - 9 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 26 IS - 4 N2 - BACKGROUND & AIMS: Despite the high mortality rate in malnourished anorexia nervosa (AN) patients, very few trials have prospectively studied the efficacy of tube feeding. METHODS: This open prospective study was conducted in malnourished AN patients, who were randomized in tube feeding (n=41) or control (n=40) groups during a 2-month period. Thereafter, body weight, body mass gain, energy intake, eating behavior and relapse rates were compared during a 1-year follow-up, using paired Student t-test and ANOVA. RESULTS: At the end of the 2-months period, weight gain was 39% higher in the tube feeding group than in the control group (194+/-14 vs 126+/-19g/day; P<0.01). The fat-free mass gain was greater in the tube-feeding group: 109+/-14 vs 61+/-17g/day (P<0.01). Energy intake was higher in the tube feeding group than in the control group (P<0.05), as well as the decrease in bingeing episodes (P<0.01). Most patients thought that CEN improved their eating disorder. After discharge, the relapse-free period was longer in the CEN group than in the control one: 34.3+/-8.2 weeks vs 26.8+/-7.5 weeks (P<0.05). CONCLUSION: CEN is helpful in malnourished AN patients for weight restoration, without hindrance on the eating behavior therapy nor inducing a more rapid relapse. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/17499892/A_randomized_trial_on_the_efficacy_of_a_2_month_tube_feeding_regimen_in_anorexia_nervosa:_A_1_year_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(07)00070-2 DB - PRIME DP - Unbound Medicine ER -