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Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Neurosci Lett. 2007 Jun 04; 419(3):253-7.NL

Abstract

This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats. Glutamate (10 and 20 mg/kg), N-methyl-d-aspartate (NMDA, 5 and 10 mg/kg), ketamine (1.5 and 2.0 mg/kg), gabapentin (200 and 250 mg/kg), phenobarbital (50 and 100 mg/kg) and vigabatrin (250 and 500 mg/kg) were administered intraperitoneally, 30 min prior to pilocarpine (400 mg/kg, i.p.). The animals were observed (24 h) to determine: number of peripheral cholinergic signs, tremors, stereotyped movements, seizures, SE, latency to first seizure and number of deaths after pilocarpine treatment. NMDA and glutamate had pro-convulsive effects in both doses tested. Smaller and higher doses of these drugs no protected and increased pilocarpine-induced seizures and/or mortality. Gabapentin, vigabatrin, phenobarbital and ketamine protected against seizures and increased the latency to first seizure. Thus, these results suggest that caution should be taken in the selection of pharmacotherapy and dosages for patients with seizures and SE because of the possibility of facility the convulsive process toxicity, SE and the mortality of adult animals in this seizures model that is similar temporal lobo epilepsy in humans.

Authors+Show Affiliations

Curso de Farmácia, Faculdade Católica Rainha do Sertão, Rua Juvêncio Alves 660, Centro, Quixadá 63900-00, CE, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17499921

Citation

Pereira, M B., et al. "Study Pharmacologic of the GABAergic and Glutamatergic Drugs On Seizures and Status Epilepticus Induced By Pilocarpine in Adult Wistar Rats." Neuroscience Letters, vol. 419, no. 3, 2007, pp. 253-7.
Pereira MB, Freitas RL, Assis MA, et al. Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. Neurosci Lett. 2007;419(3):253-7.
Pereira, M. B., Freitas, R. L., Assis, M. A., Silva, R. F., Fonteles, M. M., Freitas, R. M., & Takahashi, R. N. (2007). Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. Neuroscience Letters, 419(3), 253-7.
Pereira MB, et al. Study Pharmacologic of the GABAergic and Glutamatergic Drugs On Seizures and Status Epilepticus Induced By Pilocarpine in Adult Wistar Rats. Neurosci Lett. 2007 Jun 4;419(3):253-7. PubMed PMID: 17499921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. AU - Pereira,M B, AU - Freitas,R L M, AU - Assis,M A G, AU - Silva,R F, AU - Fonteles,M M F, AU - Freitas,R M, AU - Takahashi,R N, Y1 - 2007/04/13/ PY - 2007/01/10/received PY - 2007/03/20/revised PY - 2007/04/10/accepted PY - 2007/5/15/pubmed PY - 2007/9/29/medline PY - 2007/5/15/entrez SP - 253 EP - 7 JF - Neuroscience letters JO - Neurosci Lett VL - 419 IS - 3 N2 - This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats. Glutamate (10 and 20 mg/kg), N-methyl-d-aspartate (NMDA, 5 and 10 mg/kg), ketamine (1.5 and 2.0 mg/kg), gabapentin (200 and 250 mg/kg), phenobarbital (50 and 100 mg/kg) and vigabatrin (250 and 500 mg/kg) were administered intraperitoneally, 30 min prior to pilocarpine (400 mg/kg, i.p.). The animals were observed (24 h) to determine: number of peripheral cholinergic signs, tremors, stereotyped movements, seizures, SE, latency to first seizure and number of deaths after pilocarpine treatment. NMDA and glutamate had pro-convulsive effects in both doses tested. Smaller and higher doses of these drugs no protected and increased pilocarpine-induced seizures and/or mortality. Gabapentin, vigabatrin, phenobarbital and ketamine protected against seizures and increased the latency to first seizure. Thus, these results suggest that caution should be taken in the selection of pharmacotherapy and dosages for patients with seizures and SE because of the possibility of facility the convulsive process toxicity, SE and the mortality of adult animals in this seizures model that is similar temporal lobo epilepsy in humans. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/17499921/Study_pharmacologic_of_the_GABAergic_and_glutamatergic_drugs_on_seizures_and_status_epilepticus_induced_by_pilocarpine_in_adult_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(07)00441-7 DB - PRIME DP - Unbound Medicine ER -