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Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids.
Expert Opin Investig Drugs 2007; 16(6):877-87EO

Abstract

Historically, tobacco use was primarily recreational and has been smoked in cigarettes, cigars and pipes, as well as smokeless forms of consumption, all of which are associated with adverse health effects. However, recent scientific investigations indicate that tobacco also contains several diverse secondary metabolites that may provide potential health benefits in the treatment of cancer and neurodegenerative diseases. Specifically, the leaf and flower of Nicotiana tabacum contain high amounts of the key flavor ingredient, cembranoids. Tobacco alpha- and beta-2,7,11-cembratriene-4,6-diols display potent anticancer activity. These compounds have also been found to inhibit phorbol ester-stimulated (32)P(i) incorporation into phospholipids, induction of Epstein-Barr virus early antigen and protein phosphorylation. This review focuses on the biocatalytic and semisynthetic studies of tobacco cembanoids and their anticancer activity.

Authors+Show Affiliations

University of Louisiana at Monroe, Department of Basic Pharmaceutical Sciences, College of Pharmacy, Monroe, Louisiana 71209, USA. elsayed@ulm.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17501699

Citation

El Sayed, Khalid A., and Paul W. Sylvester. "Biocatalytic and Semisynthetic Studies of the Anticancer Tobacco Cembranoids." Expert Opinion On Investigational Drugs, vol. 16, no. 6, 2007, pp. 877-87.
El Sayed KA, Sylvester PW. Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids. Expert Opin Investig Drugs. 2007;16(6):877-87.
El Sayed, K. A., & Sylvester, P. W. (2007). Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids. Expert Opinion On Investigational Drugs, 16(6), pp. 877-87.
El Sayed KA, Sylvester PW. Biocatalytic and Semisynthetic Studies of the Anticancer Tobacco Cembranoids. Expert Opin Investig Drugs. 2007;16(6):877-87. PubMed PMID: 17501699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids. AU - El Sayed,Khalid A, AU - Sylvester,Paul W, PY - 2007/5/16/pubmed PY - 2007/7/21/medline PY - 2007/5/16/entrez SP - 877 EP - 87 JF - Expert opinion on investigational drugs JO - Expert Opin Investig Drugs VL - 16 IS - 6 N2 - Historically, tobacco use was primarily recreational and has been smoked in cigarettes, cigars and pipes, as well as smokeless forms of consumption, all of which are associated with adverse health effects. However, recent scientific investigations indicate that tobacco also contains several diverse secondary metabolites that may provide potential health benefits in the treatment of cancer and neurodegenerative diseases. Specifically, the leaf and flower of Nicotiana tabacum contain high amounts of the key flavor ingredient, cembranoids. Tobacco alpha- and beta-2,7,11-cembratriene-4,6-diols display potent anticancer activity. These compounds have also been found to inhibit phorbol ester-stimulated (32)P(i) incorporation into phospholipids, induction of Epstein-Barr virus early antigen and protein phosphorylation. This review focuses on the biocatalytic and semisynthetic studies of tobacco cembanoids and their anticancer activity. SN - 1744-7658 UR - https://www.unboundmedicine.com/medline/citation/17501699/Biocatalytic_and_semisynthetic_studies_of_the_anticancer_tobacco_cembranoids_ L2 - http://www.tandfonline.com/doi/full/10.1517/13543784.16.6.877 DB - PRIME DP - Unbound Medicine ER -