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The future of HIV prevention: prospects for an effective anti-HIV microbicide.
Infect Dis Clin North Am. 2007 Mar; 21(1):219-39, x.ID

Abstract

Topical microbicides are self-administered products for prevention of HIV transmission, and they present one of the most promising strategies for combating the HIV-AIDS epidemic. The development of microbicides is a long and complicated process, with many hurdles that are unique to this class of product, including challenges in product design, in the conduct and design of clinical trials, and in obtaining licensure of a new class of products intended for use almost exclusively in developing countries. Once they have been registered, there are additional challenges to the marketing and distribution of microbicides. An overview of the types of microbicide currently in development, and a summary of the issues and the approaches being taken to address them, are provided.

Links

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linkinghub.elsevier.com
journals.elsevierhealth.com

Authors+Show Affiliations

Nuttall J
International Partnership for Microbicides, Silver Spring, MD 20910, USA. jnuttall@ipm-microbicides.org
Romano J
No affiliation info available
Douville K
No affiliation info available
Galbreath C
No affiliation info available
Nel A
No affiliation info available
Heyward W
No affiliation info available
Mitchnick M
No affiliation info available
Walker S
No affiliation info available
Rosenberg Z
No affiliation info available

MeSH

Administration, TopicalAnti-HIV AgentsAnti-Infective Agents, LocalCCR5 Receptor AntagonistsClinical Trials as TopicDendritic CellsDisease OutbreaksDrug Resistance, ViralHIV InfectionsHIV-1HumansReceptors, CXCR4Reverse Transcriptase Inhibitors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17502237

Citation

Nuttall, Jeremy, et al. "The Future of HIV Prevention: Prospects for an Effective anti-HIV Microbicide." Infectious Disease Clinics of North America, vol. 21, no. 1, 2007, pp. 219-39, x.
Nuttall J, Romano J, Douville K, et al. The future of HIV prevention: prospects for an effective anti-HIV microbicide. Infect Dis Clin North Am. 2007;21(1):219-39, x.
Nuttall, J., Romano, J., Douville, K., Galbreath, C., Nel, A., Heyward, W., Mitchnick, M., Walker, S., & Rosenberg, Z. (2007). The future of HIV prevention: prospects for an effective anti-HIV microbicide. Infectious Disease Clinics of North America, 21(1), 219-39, x.
Nuttall J, et al. The Future of HIV Prevention: Prospects for an Effective anti-HIV Microbicide. Infect Dis Clin North Am. 2007;21(1):219-39, x. PubMed PMID: 17502237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The future of HIV prevention: prospects for an effective anti-HIV microbicide. AU - Nuttall,Jeremy, AU - Romano,Joseph, AU - Douville,Karen, AU - Galbreath,Caroline, AU - Nel,Annaléne, AU - Heyward,William, AU - Mitchnick,Mark, AU - Walker,Saul, AU - Rosenberg,Zeda, PY - 2007/5/16/pubmed PY - 2007/8/31/medline PY - 2007/5/16/entrez SP - 219-39, x JF - Infectious disease clinics of North America JO - Infect Dis Clin North Am VL - 21 IS - 1 N2 - Topical microbicides are self-administered products for prevention of HIV transmission, and they present one of the most promising strategies for combating the HIV-AIDS epidemic. The development of microbicides is a long and complicated process, with many hurdles that are unique to this class of product, including challenges in product design, in the conduct and design of clinical trials, and in obtaining licensure of a new class of products intended for use almost exclusively in developing countries. Once they have been registered, there are additional challenges to the marketing and distribution of microbicides. An overview of the types of microbicide currently in development, and a summary of the issues and the approaches being taken to address them, are provided. SN - 0891-5520 UR - https://www.unboundmedicine.com/medline/citation/17502237/The_future_of_HIV_prevention:_prospects_for_an_effective_anti_HIV_microbicide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5520(07)00010-4 DB - PRIME DP - Unbound Medicine ER -