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Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii.

Abstract

PURPOSE

To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu).

METHODS

The liver function tests of 31 healthy adult kava drinkers were compared against a control group of 31 healthy adult non-kava drinkers. Subjects were recruited from the general population, a kava bar, and Tongan kava drinking circles. The liver function profile included AST, ALT, ALP, GGT, and bilirubin (total and direct). Other tests included total protein, albumin, and screens for viral hepatitis and hemochromatosis when indicated.

RESULTS

Chronic kava beverage consumption was associated with elevation of GGT in 65% of the kava drinkers versus 26% in the controls (P = .005). ALP was elevated in 23% of kava drinkers versus 3% in the controls (P = .053).

CONCLUSION

Heavy kava beverage consumption was associated with significantly elevated GGT levels.

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  • Authors+Show Affiliations

    ,

    Department of Complementary & Alternative Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA. amybrown@hawaii.edu

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Alanine Transaminase
    Alkaline Phosphatase
    Aspartate Aminotransferases
    Beverages
    Bilirubin
    Female
    Hawaii
    Humans
    Kava
    Liver Function Tests
    Male
    Middle Aged
    Oceanic Ancestry Group
    Plant Extracts
    gamma-Glutamyltransferase

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17503265

    Citation

    Brown, Amy C., et al. "Traditional Kava Beverage Consumption and Liver Function Tests in a Predominantly Tongan Population in Hawaii." Clinical Toxicology (Philadelphia, Pa.), vol. 45, no. 5, 2007, pp. 549-56.
    Brown AC, Onopa J, Holck P, et al. Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii. Clin Toxicol (Phila). 2007;45(5):549-56.
    Brown, A. C., Onopa, J., Holck, P., Kaufusi, P., Kabasawa, D., Craig, W. J., ... Baker, J. D. (2007). Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii. Clinical Toxicology (Philadelphia, Pa.), 45(5), pp. 549-56.
    Brown AC, et al. Traditional Kava Beverage Consumption and Liver Function Tests in a Predominantly Tongan Population in Hawaii. Clin Toxicol (Phila). 2007;45(5):549-56. PubMed PMID: 17503265.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii. AU - Brown,Amy C, AU - Onopa,Janet, AU - Holck,Peter, AU - Kaufusi,Pakieli, AU - Kabasawa,Derek, AU - Craig,Winston J, AU - Dragull,Klaus, AU - Levine,Arieh M, AU - Baker,Jonathan D, PY - 2007/5/16/pubmed PY - 2007/7/31/medline PY - 2007/5/16/entrez SP - 549 EP - 56 JF - Clinical toxicology (Philadelphia, Pa.) JO - Clin Toxicol (Phila) VL - 45 IS - 5 N2 - PURPOSE: To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu). METHODS: The liver function tests of 31 healthy adult kava drinkers were compared against a control group of 31 healthy adult non-kava drinkers. Subjects were recruited from the general population, a kava bar, and Tongan kava drinking circles. The liver function profile included AST, ALT, ALP, GGT, and bilirubin (total and direct). Other tests included total protein, albumin, and screens for viral hepatitis and hemochromatosis when indicated. RESULTS: Chronic kava beverage consumption was associated with elevation of GGT in 65% of the kava drinkers versus 26% in the controls (P = .005). ALP was elevated in 23% of kava drinkers versus 3% in the controls (P = .053). CONCLUSION: Heavy kava beverage consumption was associated with significantly elevated GGT levels. SN - 1556-3650 UR - https://www.unboundmedicine.com/medline/citation/17503265/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/15563650701365875 DB - PRIME DP - Unbound Medicine ER -