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Sulfonamide allergy and cross-reactivity.
Curr Allergy Asthma Rep 2007; 7(1):41-8CA

Abstract

Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic sulfonamide-containing drugs continue to complicate pharmacotherapy. Several elegant investigations have demonstrated unequivocal lack of interaction between the sulfonamide group and either cellular or humoral immunity. The immunologic determinant of type I immunologic responses to sulfonamide antibiotics is the N1 heterocyclic ring, and nonantibiotic sulfonamides lack this structural feature. Many non-type I hypersensitivity responses to sulfonamide antibiotics are attributable to reactive metabolites that cause either direct cytotoxicity or humoral or cellular responses. Metabolite formation is stereospecific to the N4 amino nitrogen of the sulfonamide antibiotics, a structure not found on any nonantibiotic sulfonamide drugs. Cellular immune responses to sulfonamide antibiotics are responsible for many non-immunoglobulin E-mediated dermatologic reactions; however, the stereospecificity of T-cell response renders cross-reactivity between sulfonamide antibiotics and nonantibiotics highly unlikely. Apparent cross-reactivity responses to sulfonamide-containing drugs likely represent multiple concurrent, rather than linked, drug hypersensitivities.

Authors+Show Affiliations

The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA. brackett.2@osu.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17504660

Citation

Brackett, Carolyn C.. "Sulfonamide Allergy and Cross-reactivity." Current Allergy and Asthma Reports, vol. 7, no. 1, 2007, pp. 41-8.
Brackett CC. Sulfonamide allergy and cross-reactivity. Curr Allergy Asthma Rep. 2007;7(1):41-8.
Brackett, C. C. (2007). Sulfonamide allergy and cross-reactivity. Current Allergy and Asthma Reports, 7(1), pp. 41-8.
Brackett CC. Sulfonamide Allergy and Cross-reactivity. Curr Allergy Asthma Rep. 2007;7(1):41-8. PubMed PMID: 17504660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfonamide allergy and cross-reactivity. A1 - Brackett,Carolyn C, PY - 2007/5/17/pubmed PY - 2007/6/1/medline PY - 2007/5/17/entrez SP - 41 EP - 8 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 7 IS - 1 N2 - Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic sulfonamide-containing drugs continue to complicate pharmacotherapy. Several elegant investigations have demonstrated unequivocal lack of interaction between the sulfonamide group and either cellular or humoral immunity. The immunologic determinant of type I immunologic responses to sulfonamide antibiotics is the N1 heterocyclic ring, and nonantibiotic sulfonamides lack this structural feature. Many non-type I hypersensitivity responses to sulfonamide antibiotics are attributable to reactive metabolites that cause either direct cytotoxicity or humoral or cellular responses. Metabolite formation is stereospecific to the N4 amino nitrogen of the sulfonamide antibiotics, a structure not found on any nonantibiotic sulfonamide drugs. Cellular immune responses to sulfonamide antibiotics are responsible for many non-immunoglobulin E-mediated dermatologic reactions; however, the stereospecificity of T-cell response renders cross-reactivity between sulfonamide antibiotics and nonantibiotics highly unlikely. Apparent cross-reactivity responses to sulfonamide-containing drugs likely represent multiple concurrent, rather than linked, drug hypersensitivities. SN - 1529-7322 UR - https://www.unboundmedicine.com/medline/citation/17504660/Sulfonamide_allergy_and_cross_reactivity_ L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -