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Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV(1) between patients with asymptomatic bronchial hyperresponsiveness and mild asthma.
Chest. 2007 Jul; 132(1):106-11.Chest

Abstract

BACKGROUND

A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV(1) (PC(20)). The percentage fall in FVC at the PC(20) (DeltaFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC(20). The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to DeltaFVC.

METHODS

Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC(20) < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC(20) were selected (mild asthma group). The DeltaFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups.

RESULTS

There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (+/- SD) DeltaFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 +/- 3.6%) than in the mild asthma group (16.9 +/- 4.3%).

CONCLUSIONS

Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR.

Authors+Show Affiliations

Department of Pediatrics, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

17505037

Citation

Yoo, Young, et al. "Comparison of Percentage Fall in FVC at the Provocative Concentration of Methacholine Causing a 20% Fall in FEV(1) Between Patients With Asymptomatic Bronchial Hyperresponsiveness and Mild Asthma." Chest, vol. 132, no. 1, 2007, pp. 106-11.
Yoo Y, Choung JT, Yu J, et al. Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV(1) between patients with asymptomatic bronchial hyperresponsiveness and mild asthma. Chest. 2007;132(1):106-11.
Yoo, Y., Choung, J. T., Yu, J., Kim, D. K., Choi, S. H., & Koh, Y. Y. (2007). Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV(1) between patients with asymptomatic bronchial hyperresponsiveness and mild asthma. Chest, 132(1), 106-11.
Yoo Y, et al. Comparison of Percentage Fall in FVC at the Provocative Concentration of Methacholine Causing a 20% Fall in FEV(1) Between Patients With Asymptomatic Bronchial Hyperresponsiveness and Mild Asthma. Chest. 2007;132(1):106-11. PubMed PMID: 17505037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV(1) between patients with asymptomatic bronchial hyperresponsiveness and mild asthma. AU - Yoo,Young, AU - Choung,Ji Tae, AU - Yu,Jinho, AU - Kim,Do Kyun, AU - Choi,Sun Hee, AU - Koh,Young Yull, Y1 - 2007/05/15/ PY - 2007/5/17/pubmed PY - 2007/8/19/medline PY - 2007/5/17/entrez SP - 106 EP - 11 JF - Chest JO - Chest VL - 132 IS - 1 N2 - BACKGROUND: A significant proportion of individuals who have no symptoms of asthma or other respiratory diseases show bronchial hyperresponsiveness (BHR). BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV(1) (PC(20)). The percentage fall in FVC at the PC(20) (DeltaFVC) has been suggested to reflect maximal airway response and to be a more useful index of disease severity in asthma than PC(20). The aim of this study was to investigate whether asymptomatic BHR would differ from symptomatic BHR with regard to DeltaFVC. METHODS: Methacholine bronchial challenge tests were conducted in children with no past or current symptoms of asthma, allergic rhinitis, or other respiratory diseases, who were identified among siblings of children with asthma. Forty-three children with asymptomatic BHR (PC(20) < 16 mg/mL) were recruited, and 43 children with mild asthma who were matched for age, sex, and PC(20) were selected (mild asthma group). The DeltaFVC on methacholine concentration-response curves was retrospectively analyzed in the two groups. RESULTS: There were no differences in the frequency of atopy, blood eosinophil counts, serum IgE levels, and spirometric values between the asymptomatic BHR and mild asthma groups. Mean (+/- SD) DeltaFVC was significantly (p = 0.005) lower in the asymptomatic BHR group (14.5 +/- 3.6%) than in the mild asthma group (16.9 +/- 4.3%). CONCLUSIONS: Our results suggest that children with asymptomatic BHR have a lower level of maximal airway response than mild asthmatics with a similar degree of BHR. This may be a possible explanation for the lack of symptoms in subjects with asymptomatic BHR. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/17505037/Comparison_of_percentage_fall_in_FVC_at_the_provocative_concentration_of_methacholine_causing_a_20_fall_in_FEV_1__between_patients_with_asymptomatic_bronchial_hyperresponsiveness_and_mild_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)35691-9 DB - PRIME DP - Unbound Medicine ER -