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Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Abstract

BACKGROUND

At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor.

METHODS

We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case-control studies that included 10,244 head and neck cancer case subjects and 15,227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided.

RESULTS

Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose-response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx.

CONCLUSIONS

Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.

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  • Authors+Show Affiliations

    ,

    Gene-Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France. hashibe@iarc.fr

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    Source

    Journal of the National Cancer Institute 99:10 2007 May 16 pg 777-89

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Case-Control Studies
    Female
    Head and Neck Neoplasms
    Humans
    Male
    Middle Aged
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    17505073

    Citation

    Hashibe, Mia, et al. "Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium." Journal of the National Cancer Institute, vol. 99, no. 10, 2007, pp. 777-89.
    Hashibe M, Brennan P, Benhamou S, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007;99(10):777-89.
    Hashibe, M., Brennan, P., Benhamou, S., Castellsague, X., Chen, C., Curado, M. P., ... Boffetta, P. (2007). Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Journal of the National Cancer Institute, 99(10), pp. 777-89.
    Hashibe M, et al. Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007 May 16;99(10):777-89. PubMed PMID: 17505073.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. AU - Hashibe,Mia, AU - Brennan,Paul, AU - Benhamou,Simone, AU - Castellsague,Xavier, AU - Chen,Chu, AU - Curado,Maria Paula, AU - Dal Maso,Luigino, AU - Daudt,Alexander W, AU - Fabianova,Eleonora, AU - Fernandez,Leticia, AU - Wünsch-Filho,Victor, AU - Franceschi,Silvia, AU - Hayes,Richard B, AU - Herrero,Rolando, AU - Koifman,Sergio, AU - La Vecchia,Carlo, AU - Lazarus,Philip, AU - Levi,Fabio, AU - Mates,Dana, AU - Matos,Elena, AU - Menezes,Ana, AU - Muscat,Joshua, AU - Eluf-Neto,Jose, AU - Olshan,Andrew F, AU - Rudnai,Peter, AU - Schwartz,Stephen M, AU - Smith,Elaine, AU - Sturgis,Erich M, AU - Szeszenia-Dabrowska,Neonilia, AU - Talamini,Renato, AU - Wei,Qingyi, AU - Winn,Deborah M, AU - Zaridze,David, AU - Zatonski,Witold, AU - Zhang,Zuo-Feng, AU - Berthiller,Julien, AU - Boffetta,Paolo, PY - 2007/5/17/pubmed PY - 2007/7/13/medline PY - 2007/5/17/entrez SP - 777 EP - 89 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 99 IS - 10 N2 - BACKGROUND: At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. METHODS: We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case-control studies that included 10,244 head and neck cancer case subjects and 15,227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. RESULTS: Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose-response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. CONCLUSIONS: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/17505073/Alcohol_drinking_in_never_users_of_tobacco_cigarette_smoking_in_never_drinkers_and_the_risk_of_head_and_neck_cancer:_pooled_analysis_in_the_International_Head_and_Neck_Cancer_Epidemiology_Consortium_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djk179 DB - PRIME DP - Unbound Medicine ER -