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Detection of some safe plant-derived foods for LTP-allergic patients.
Int Arch Allergy Immunol 2007; 144(1):57-63IA

Abstract

BACKGROUND

Lipid transfer protein (LTP) is a widely cross-reacting plant pan-allergen. Adverse reactions to Rosaceae, tree nuts, peanut, beer, maize, mustard, asparagus, grapes, mulberry, cabbage, dates, orange, fig, kiwi, lupine, fennel, celery, tomato, eggplant, lettuce, chestnut and pineapple have been recorded.

OBJECTIVE

To detect vegetable foods to be regarded as safe for LTP-allergic patients.

METHODS

Tolerance/intolerance to a large spectrum of vegetable foods other than Rosaceae, tree nuts and peanut was assessed by interview in 49 subjects monosensitized to LTP and in three distinct groups of controls monosensitized to Bet v 1 (n = 24) or Bet v 2 (n = 18), or sensitized to both LTP and birch pollen (n = 16), all with a history of vegetable food allergy. Patients and controls underwent skin prick test (SPT) with a large spectrum of vegetable foods. The absence of IgE reactivity to foods that were negative in both clinical history and SPT was confirmed by immunoblot analysis and their clinical tolerance was finally assessed by open oral challenge (50 g per food).

RESULTS

All patients reported tolerance and showed negative SPT to carrot, potato, banana and melon; these foods scored positive in SPT and elicited clinical symptoms in a significant proportion of patients from all three control groups. All patients tolerated these four foods on oral challenge. Immunoblot analysis confirmed the lack of IgE reactivity to these foods by LTP-allergic patients.

CONCLUSION

Carrot, potato, banana and melon seem safe for LTP-allergic patients. This finding may be helpful for a better management of allergy to LTP.

Authors+Show Affiliations

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italia. r.asero@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17505138

Citation

Asero, Riccardo, et al. "Detection of some Safe Plant-derived Foods for LTP-allergic Patients." International Archives of Allergy and Immunology, vol. 144, no. 1, 2007, pp. 57-63.
Asero R, Mistrello G, Roncarolo D, et al. Detection of some safe plant-derived foods for LTP-allergic patients. Int Arch Allergy Immunol. 2007;144(1):57-63.
Asero, R., Mistrello, G., Roncarolo, D., & Amato, S. (2007). Detection of some safe plant-derived foods for LTP-allergic patients. International Archives of Allergy and Immunology, 144(1), pp. 57-63.
Asero R, et al. Detection of some Safe Plant-derived Foods for LTP-allergic Patients. Int Arch Allergy Immunol. 2007;144(1):57-63. PubMed PMID: 17505138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of some safe plant-derived foods for LTP-allergic patients. AU - Asero,Riccardo, AU - Mistrello,Gianni, AU - Roncarolo,Daniela, AU - Amato,Stefano, Y1 - 2007/05/14/ PY - 2006/10/06/received PY - 2007/02/20/accepted PY - 2007/5/17/pubmed PY - 2007/8/29/medline PY - 2007/5/17/entrez SP - 57 EP - 63 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 144 IS - 1 N2 - BACKGROUND: Lipid transfer protein (LTP) is a widely cross-reacting plant pan-allergen. Adverse reactions to Rosaceae, tree nuts, peanut, beer, maize, mustard, asparagus, grapes, mulberry, cabbage, dates, orange, fig, kiwi, lupine, fennel, celery, tomato, eggplant, lettuce, chestnut and pineapple have been recorded. OBJECTIVE: To detect vegetable foods to be regarded as safe for LTP-allergic patients. METHODS: Tolerance/intolerance to a large spectrum of vegetable foods other than Rosaceae, tree nuts and peanut was assessed by interview in 49 subjects monosensitized to LTP and in three distinct groups of controls monosensitized to Bet v 1 (n = 24) or Bet v 2 (n = 18), or sensitized to both LTP and birch pollen (n = 16), all with a history of vegetable food allergy. Patients and controls underwent skin prick test (SPT) with a large spectrum of vegetable foods. The absence of IgE reactivity to foods that were negative in both clinical history and SPT was confirmed by immunoblot analysis and their clinical tolerance was finally assessed by open oral challenge (50 g per food). RESULTS: All patients reported tolerance and showed negative SPT to carrot, potato, banana and melon; these foods scored positive in SPT and elicited clinical symptoms in a significant proportion of patients from all three control groups. All patients tolerated these four foods on oral challenge. Immunoblot analysis confirmed the lack of IgE reactivity to these foods by LTP-allergic patients. CONCLUSION: Carrot, potato, banana and melon seem safe for LTP-allergic patients. This finding may be helpful for a better management of allergy to LTP. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/17505138/Detection_of_some_safe_plant_derived_foods_for_LTP_allergic_patients_ L2 - https://www.karger.com?DOI=10.1159/000102615 DB - PRIME DP - Unbound Medicine ER -