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Neuropsychological frontal impairments and negative symptoms in schizophrenia.
Psychiatry Res. 2007 Aug 30; 152(2-3):121-8.PR

Abstract

Negative symptoms have been associated with frontal lobe dysfunction in schizophrenia. However, neuropsychological studies that evaluated the correlation between performance in tests sensitive to the dorsolateral prefrontal cortex (DLPFC) and negative symptoms have shown inconsistent results. Growing evidence has appeared that not only the DLPFC but other prefrontal regions could be involved in schizophrenia. We evaluated schizophrenic patients and healthy controls using three "frontal tests": the Wisconsin Card Sorting Test (WCST), the Iowa Gambling Task (GT) and a Theory of Mind test (Faux Pas), and studied the relationship between performance in these tests and negative symptomatology. Schizophrenic patients had worse performance than normal controls on the WCST, GT and Faux Pas test. The severity of the negative symptoms showed a moderate to high correlation with performance in the Faux Pas test. Our findings support the idea that different prefrontal regions could be affected in people with schizophrenia and that the damage to each of these regions could be, at least in part, independent of the damage to the others. Some negative symptoms could be associated with frontal medial cortex dysfunction.

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Authors+Show Affiliations

Martino DJ
Alvear Psychiatric Hospital, G.C.B.A. Buenos Aires, Argentina. diejmartino@yahoo.com.ar
Bucay D
No affiliation info available
Butman JT
No affiliation info available
Allegri RF
No affiliation info available

MeSH

AdolescentAdultCognition DisordersFemaleFrontal LobeGamblingHumansMaleMiddle AgedNeuropsychological TestsPrefrontal CortexPsychological TestsSchizophreniaSeverity of Illness Index

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17507100

Citation

Martino, Diego J., et al. "Neuropsychological Frontal Impairments and Negative Symptoms in Schizophrenia." Psychiatry Research, vol. 152, no. 2-3, 2007, pp. 121-8.
Martino DJ, Bucay D, Butman JT, et al. Neuropsychological frontal impairments and negative symptoms in schizophrenia. Psychiatry Res. 2007;152(2-3):121-8.
Martino, D. J., Bucay, D., Butman, J. T., & Allegri, R. F. (2007). Neuropsychological frontal impairments and negative symptoms in schizophrenia. Psychiatry Research, 152(2-3), 121-8.
Martino DJ, et al. Neuropsychological Frontal Impairments and Negative Symptoms in Schizophrenia. Psychiatry Res. 2007 Aug 30;152(2-3):121-8. PubMed PMID: 17507100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychological frontal impairments and negative symptoms in schizophrenia. AU - Martino,Diego J, AU - Bucay,Demián, AU - Butman,Judith T, AU - Allegri,Ricardo F, Y1 - 2007/05/15/ PY - 2005/03/20/received PY - 2006/01/08/revised PY - 2006/03/03/accepted PY - 2007/5/18/pubmed PY - 2007/12/8/medline PY - 2007/5/18/entrez SP - 121 EP - 8 JF - Psychiatry research JO - Psychiatry Res VL - 152 IS - 2-3 N2 - Negative symptoms have been associated with frontal lobe dysfunction in schizophrenia. However, neuropsychological studies that evaluated the correlation between performance in tests sensitive to the dorsolateral prefrontal cortex (DLPFC) and negative symptoms have shown inconsistent results. Growing evidence has appeared that not only the DLPFC but other prefrontal regions could be involved in schizophrenia. We evaluated schizophrenic patients and healthy controls using three "frontal tests": the Wisconsin Card Sorting Test (WCST), the Iowa Gambling Task (GT) and a Theory of Mind test (Faux Pas), and studied the relationship between performance in these tests and negative symptomatology. Schizophrenic patients had worse performance than normal controls on the WCST, GT and Faux Pas test. The severity of the negative symptoms showed a moderate to high correlation with performance in the Faux Pas test. Our findings support the idea that different prefrontal regions could be affected in people with schizophrenia and that the damage to each of these regions could be, at least in part, independent of the damage to the others. Some negative symptoms could be associated with frontal medial cortex dysfunction. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/17507100/Neuropsychological_frontal_impairments_and_negative_symptoms_in_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(06)00063-1 DB - PRIME DP - Unbound Medicine ER -