Tags

Type your tag names separated by a space and hit enter

Controlling of systemic absorption of gliclazide through incorporation into alginate beads.
Int J Pharm. 2007 Aug 16; 341(1-2):230-7.IJ

Abstract

This work investigates preparation of biodegradable beads with alginate polymer by ionotropic gelation method to take the advantages of the swelling and mucoadhesive properties of alginate beads for improving the oral delivery of the antidiabetic agent gliclazide. It demonstrates that the ionic gelation of alginate molecules offers a flexible and easily controllable process for manipulating the characteristics of the beads which are important in controlling the release rate and consequently the absorption of gliclazide from the gastrointestinal tract. Variations in polymer concentration, stirring speed, internal phase volume and the type of surfactant in the external phase were examined systemically for their effects on the particle size, incorporation efficiency and flow properties of the beads. The swelling behavior was strongly dependent on the polymer concentration in the formulations and the pH of the medium. The in vitro release experiments revealed that the swelling is the main parameter controlling the release rate of gliclazide from the beads. In vivo studies on diabetic rabbits showed that the hypoglycemic effect induced by the gliclazide loaded alginate beads was significantly greater and more prolonged than that induced by the marketed conventional gliclazide tablet (Gliclazide). The results clearly demonstrated the ability of the system to maintain tight blood glucose level and improved the patient compliance by enhancing, controlling and prolonging the systemic absorption of gliclazide.

Authors+Show Affiliations

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 17221, Riyadh 11484, Saudi Arabia. Kassas_r2@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17507189

Citation

Al-Kassas, Raida S., et al. "Controlling of Systemic Absorption of Gliclazide Through Incorporation Into Alginate Beads." International Journal of Pharmaceutics, vol. 341, no. 1-2, 2007, pp. 230-7.
Al-Kassas RS, Al-Gohary OM, Al-Faadhel MM. Controlling of systemic absorption of gliclazide through incorporation into alginate beads. Int J Pharm. 2007;341(1-2):230-7.
Al-Kassas, R. S., Al-Gohary, O. M., & Al-Faadhel, M. M. (2007). Controlling of systemic absorption of gliclazide through incorporation into alginate beads. International Journal of Pharmaceutics, 341(1-2), 230-7.
Al-Kassas RS, Al-Gohary OM, Al-Faadhel MM. Controlling of Systemic Absorption of Gliclazide Through Incorporation Into Alginate Beads. Int J Pharm. 2007 Aug 16;341(1-2):230-7. PubMed PMID: 17507189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlling of systemic absorption of gliclazide through incorporation into alginate beads. AU - Al-Kassas,Raida S, AU - Al-Gohary,Omaimah M N, AU - Al-Faadhel,Monirah M, Y1 - 2007/04/05/ PY - 2006/03/09/received PY - 2007/03/01/revised PY - 2007/03/29/accepted PY - 2007/5/18/pubmed PY - 2007/9/22/medline PY - 2007/5/18/entrez SP - 230 EP - 7 JF - International journal of pharmaceutics JO - Int J Pharm VL - 341 IS - 1-2 N2 - This work investigates preparation of biodegradable beads with alginate polymer by ionotropic gelation method to take the advantages of the swelling and mucoadhesive properties of alginate beads for improving the oral delivery of the antidiabetic agent gliclazide. It demonstrates that the ionic gelation of alginate molecules offers a flexible and easily controllable process for manipulating the characteristics of the beads which are important in controlling the release rate and consequently the absorption of gliclazide from the gastrointestinal tract. Variations in polymer concentration, stirring speed, internal phase volume and the type of surfactant in the external phase were examined systemically for their effects on the particle size, incorporation efficiency and flow properties of the beads. The swelling behavior was strongly dependent on the polymer concentration in the formulations and the pH of the medium. The in vitro release experiments revealed that the swelling is the main parameter controlling the release rate of gliclazide from the beads. In vivo studies on diabetic rabbits showed that the hypoglycemic effect induced by the gliclazide loaded alginate beads was significantly greater and more prolonged than that induced by the marketed conventional gliclazide tablet (Gliclazide). The results clearly demonstrated the ability of the system to maintain tight blood glucose level and improved the patient compliance by enhancing, controlling and prolonging the systemic absorption of gliclazide. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17507189/Controlling_of_systemic_absorption_of_gliclazide_through_incorporation_into_alginate_beads_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(07)00289-X DB - PRIME DP - Unbound Medicine ER -