Tags

Type your tag names separated by a space and hit enter

The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection.
J Clin Virol. 2007 Jun; 39(2):76-81.JC

Abstract

BACKGROUND

Dengue haemorrhagic fever is an important public health problem and mainly occurs in children less than 15 years of age. Recently, the incidence of the disease have increased in adults but data on clinical and laboratory presentations of those affected are limited.

OBJECTIVES

To assess and compare clinical manifestations and laboratory findings of dengue virus infected children and adults in Thailand.

STUDY DESIGN

A 1-year study was conducted from September 2003 to August 2004 for dengue virus infected patients admitted to Phetchabun Provincial Hospital, Thailand. Physical signs, symptoms, and laboratory features were recorded. All dengue patients were confirmed using immunochromatographic test on convalescent sera.

RESULTS

Based on serology-confirmed dengue virus infection, there was 286 dengue patients including 15 (5.3%) dengue fever and 271 (94.7%) dengue haemorrhagic fever (DHF). Among DHF cases, clinical classifications were DHF I, 40.9%; DHF II, 43%; and DHF III or dengue shock syndrome (DSS), 10.8%. Of all dengue patients, 231 cases (80.8%) were children aged less than 15 years and 55 cases (19.2%) were adults. The highest proportion of child cases was DHF I (42.9%), whereas that of adults was DHF II (51%). Some clinical manifestations were more common in adult patients, such as petechiae, melena, headache, retro-orbital pain, joint pain, myalgia, nausea and vomiting (p-value<0.05). Signs found commonly in children were epistaxis, oliguria, and liver enlargement (p-value<0.05). Haemoconcentration, thrombocytopenia, increased alanine aminotransferase, and longer prothrombin time were found to be significantly higher in adults than in children (p-value<0.05).

CONCLUSIONS

Some clinical presentations of dengue disease and laboratory findings in adults are different from those in children. Therefore, adults as well as pediatric cases of DHF need appropriate and prompt case management to reduce the mortality rate of DHF.

Authors+Show Affiliations

Department of Microbiology, Faculty of Public Health, Mahidol University, Bangkok, Thailand. phlkt@mahidol.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17507286

Citation

Kittigul, Leera, et al. "The Differences of Clinical Manifestations and Laboratory Findings in Children and Adults With Dengue Virus Infection." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 39, no. 2, 2007, pp. 76-81.
Kittigul L, Pitakarnjanakul P, Sujirarat D, et al. The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection. J Clin Virol. 2007;39(2):76-81.
Kittigul, L., Pitakarnjanakul, P., Sujirarat, D., & Siripanichgon, K. (2007). The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 39(2), 76-81.
Kittigul L, et al. The Differences of Clinical Manifestations and Laboratory Findings in Children and Adults With Dengue Virus Infection. J Clin Virol. 2007;39(2):76-81. PubMed PMID: 17507286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The differences of clinical manifestations and laboratory findings in children and adults with dengue virus infection. AU - Kittigul,Leera, AU - Pitakarnjanakul,Piyamard, AU - Sujirarat,Dusit, AU - Siripanichgon,Kanokrat, Y1 - 2007/05/15/ PY - 2006/10/30/received PY - 2007/02/02/revised PY - 2007/04/04/accepted PY - 2007/5/18/pubmed PY - 2007/7/25/medline PY - 2007/5/18/entrez SP - 76 EP - 81 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 39 IS - 2 N2 - BACKGROUND: Dengue haemorrhagic fever is an important public health problem and mainly occurs in children less than 15 years of age. Recently, the incidence of the disease have increased in adults but data on clinical and laboratory presentations of those affected are limited. OBJECTIVES: To assess and compare clinical manifestations and laboratory findings of dengue virus infected children and adults in Thailand. STUDY DESIGN: A 1-year study was conducted from September 2003 to August 2004 for dengue virus infected patients admitted to Phetchabun Provincial Hospital, Thailand. Physical signs, symptoms, and laboratory features were recorded. All dengue patients were confirmed using immunochromatographic test on convalescent sera. RESULTS: Based on serology-confirmed dengue virus infection, there was 286 dengue patients including 15 (5.3%) dengue fever and 271 (94.7%) dengue haemorrhagic fever (DHF). Among DHF cases, clinical classifications were DHF I, 40.9%; DHF II, 43%; and DHF III or dengue shock syndrome (DSS), 10.8%. Of all dengue patients, 231 cases (80.8%) were children aged less than 15 years and 55 cases (19.2%) were adults. The highest proportion of child cases was DHF I (42.9%), whereas that of adults was DHF II (51%). Some clinical manifestations were more common in adult patients, such as petechiae, melena, headache, retro-orbital pain, joint pain, myalgia, nausea and vomiting (p-value<0.05). Signs found commonly in children were epistaxis, oliguria, and liver enlargement (p-value<0.05). Haemoconcentration, thrombocytopenia, increased alanine aminotransferase, and longer prothrombin time were found to be significantly higher in adults than in children (p-value<0.05). CONCLUSIONS: Some clinical presentations of dengue disease and laboratory findings in adults are different from those in children. Therefore, adults as well as pediatric cases of DHF need appropriate and prompt case management to reduce the mortality rate of DHF. SN - 1386-6532 UR - https://www.unboundmedicine.com/medline/citation/17507286/The_differences_of_clinical_manifestations_and_laboratory_findings_in_children_and_adults_with_dengue_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(07)00135-7 DB - PRIME DP - Unbound Medicine ER -