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Two cases of severe obstructive pneumonia associated with an HKU1-like coronavirus.
Eur J Med Res. 2007 Mar 26; 12(3):134-8.EJ

Abstract

BACKGROUND

During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections.

OBJECTIVES

Nasopharyngeal samples from hospitalized pediatric patients with respiratory disease were analysed for the presence of coronaviruses and other well known and newly identified respiratory viruses.

RESULTS

Two clinical cases of a severe obstructive pneumonia, which were associated with the presence of RNA of a novel variant (subtype) of HKU1 coronavirus in the nasopharyngeal aspirates, were identified.

DISCUSSION

The detection of a HKU1-like coronavirus in pediatric patients in the current study complement the most recent independent finding of similar or closely related coronaviruses in patients with respiratory diseases in France (Vabret et al. 2006) and Norway (Jonassen et al., see accompanying manuscript). These observations indicate a wide dissemination of HKU1-like coronaviruses in Europe.

Authors+Show Affiliations

Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17507310

Citation

Kupfer, B, et al. "Two Cases of Severe Obstructive Pneumonia Associated With an HKU1-like Coronavirus." European Journal of Medical Research, vol. 12, no. 3, 2007, pp. 134-8.
Kupfer B, Simon A, Jonassen CM, et al. Two cases of severe obstructive pneumonia associated with an HKU1-like coronavirus. Eur J Med Res. 2007;12(3):134-8.
Kupfer, B., Simon, A., Jonassen, C. M., Viazov, S., Ditt, V., Tillmann, R. L., Müller, A., Matz, B., & Schildgen, O. (2007). Two cases of severe obstructive pneumonia associated with an HKU1-like coronavirus. European Journal of Medical Research, 12(3), 134-8.
Kupfer B, et al. Two Cases of Severe Obstructive Pneumonia Associated With an HKU1-like Coronavirus. Eur J Med Res. 2007 Mar 26;12(3):134-8. PubMed PMID: 17507310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two cases of severe obstructive pneumonia associated with an HKU1-like coronavirus. AU - Kupfer,B, AU - Simon,A, AU - Jonassen,C M, AU - Viazov,S, AU - Ditt,V, AU - Tillmann,R-L, AU - Müller,A, AU - Matz,B, AU - Schildgen,O, PY - 2007/5/18/pubmed PY - 2007/6/7/medline PY - 2007/5/18/entrez SP - 134 EP - 8 JF - European journal of medical research JO - Eur J Med Res VL - 12 IS - 3 N2 - BACKGROUND: During the last few years a number of previously undescribed viruses, including human metapneumovirus, coronaviruses SARS, NL63 and HKU1, and bocavirus, were identified in nasopharyngeal samples from patients with signs of respiratory infections. These viruses may cause mild to life-threatening infections. OBJECTIVES: Nasopharyngeal samples from hospitalized pediatric patients with respiratory disease were analysed for the presence of coronaviruses and other well known and newly identified respiratory viruses. RESULTS: Two clinical cases of a severe obstructive pneumonia, which were associated with the presence of RNA of a novel variant (subtype) of HKU1 coronavirus in the nasopharyngeal aspirates, were identified. DISCUSSION: The detection of a HKU1-like coronavirus in pediatric patients in the current study complement the most recent independent finding of similar or closely related coronaviruses in patients with respiratory diseases in France (Vabret et al. 2006) and Norway (Jonassen et al., see accompanying manuscript). These observations indicate a wide dissemination of HKU1-like coronaviruses in Europe. SN - 0949-2321 UR - https://www.unboundmedicine.com/medline/citation/17507310/Two_cases_of_severe_obstructive_pneumonia_associated_with_an_HKU1_like_coronavirus_ DB - PRIME DP - Unbound Medicine ER -