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Antioxidant intake and cognitive function of elderly men and women: the Cache County Study.
J Nutr Health Aging 2007 May-Jun; 11(3):230-7JN

Abstract

OBJECTIVE

We prospectively examined associations between intakes of antioxidants (vitamins C, vitamin E, and carotene) and cognitive function and decline among elderly men and women of the Cache County Study on Memory and Aging in Utah.

PARTICIPANTS AND DESIGN

In 1995, 3831 residents 65 years of age or older completed a baseline survey that included a food frequency questionnaire and cognitive assessment. Cognitive function was assessed using an adapted version of the Modified Mini-Mental State examination (3MS) at baseline and at three subsequent follow-up interviews spanning approximately 7 years. Multivariable-mixed models were used to estimate antioxidant nutrient effects on average 3MS score over time.

RESULTS

Increasing quartiles of vitamin C intake alone and combined with vitamin E were associated with higher baseline average 3MS scores (p-trend = 0.013 and 0.02 respectively); this association appeared stronger for food sources compared to supplement or food and supplement sources combined. Study participants with lower levels of intake of vitamin C, vitamin E and carotene had a greater acceleration of the rate of 3MS decline over time compared to those with higher levels of intake.

CONCLUSION

High antioxidant intake from food and supplement sources of vitamin C, vitamin E, and carotene may delay cognitive decline in the elderly.

Authors+Show Affiliations

Department of Nutrition and Food Sciences and Center for Epidemiologic Research, Utah State University, Logan, UT 84322-8700, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17508099

Citation

Wengreen, H J., et al. "Antioxidant Intake and Cognitive Function of Elderly Men and Women: the Cache County Study." The Journal of Nutrition, Health & Aging, vol. 11, no. 3, 2007, pp. 230-7.
Wengreen HJ, Munger RG, Corcoran CD, et al. Antioxidant intake and cognitive function of elderly men and women: the Cache County Study. J Nutr Health Aging. 2007;11(3):230-7.
Wengreen, H. J., Munger, R. G., Corcoran, C. D., Zandi, P., Hayden, K. M., Fotuhi, M., ... Welsh-Bohmer, K. A. (2007). Antioxidant intake and cognitive function of elderly men and women: the Cache County Study. The Journal of Nutrition, Health & Aging, 11(3), pp. 230-7.
Wengreen HJ, et al. Antioxidant Intake and Cognitive Function of Elderly Men and Women: the Cache County Study. J Nutr Health Aging. 2007;11(3):230-7. PubMed PMID: 17508099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant intake and cognitive function of elderly men and women: the Cache County Study. AU - Wengreen,H J, AU - Munger,R G, AU - Corcoran,C D, AU - Zandi,P, AU - Hayden,K M, AU - Fotuhi,M, AU - Skoog,I, AU - Norton,M C, AU - Tschanz,J, AU - Breitner,J C S, AU - Welsh-Bohmer,K A, PY - 2007/5/18/pubmed PY - 2007/8/1/medline PY - 2007/5/18/entrez SP - 230 EP - 7 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 11 IS - 3 N2 - OBJECTIVE: We prospectively examined associations between intakes of antioxidants (vitamins C, vitamin E, and carotene) and cognitive function and decline among elderly men and women of the Cache County Study on Memory and Aging in Utah. PARTICIPANTS AND DESIGN: In 1995, 3831 residents 65 years of age or older completed a baseline survey that included a food frequency questionnaire and cognitive assessment. Cognitive function was assessed using an adapted version of the Modified Mini-Mental State examination (3MS) at baseline and at three subsequent follow-up interviews spanning approximately 7 years. Multivariable-mixed models were used to estimate antioxidant nutrient effects on average 3MS score over time. RESULTS: Increasing quartiles of vitamin C intake alone and combined with vitamin E were associated with higher baseline average 3MS scores (p-trend = 0.013 and 0.02 respectively); this association appeared stronger for food sources compared to supplement or food and supplement sources combined. Study participants with lower levels of intake of vitamin C, vitamin E and carotene had a greater acceleration of the rate of 3MS decline over time compared to those with higher levels of intake. CONCLUSION: High antioxidant intake from food and supplement sources of vitamin C, vitamin E, and carotene may delay cognitive decline in the elderly. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/17508099/Antioxidant_intake_and_cognitive_function_of_elderly_men_and_women:_the_Cache_County_Study_ L2 - https://medlineplus.gov/vitaminc.html DB - PRIME DP - Unbound Medicine ER -