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Neurophysiology and neuromodulators.
Neurol Sci 2007; 28 Suppl 2:S97-S100NS

Abstract

Migraine is an episodic brain disorder that results in significant morbidity. Antiepileptic drugs (neuromodulators) are increasingly recommended for migraine prevention because of placebo-controlled double-blind trials that prove them effective. Cortical spreading depression (CSD) is thought to be the pathophysiological correlate of the neurological symptoms in migraine with aura and neuromodulators may act on mechanisms involved in the initiation of CSD itself. Inhibition of trigeminocervical complex directly, or neurons that modulate sensory input, are also plausible mechanisms for the actions of neuromodulators in preventive therapy in migraine. Although it is unlikely that a single phenomenon serves as the only link between migraine and epilepsy, the neuronal hyperexcitability that may contribute to each condition may explain the effect of these drugs for both conditions.

Authors+Show Affiliations

Neurological Department, Via E. Raggio 12, I-15057 Novi Ligure (AL), Italy. aguggiamarco@tiscali.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17508189

Citation

Aguggia, M, et al. "Neurophysiology and Neuromodulators." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 28 Suppl 2, 2007, pp. S97-S100.
Aguggia M, D'Andrea G, Bussone G. Neurophysiology and neuromodulators. Neurol Sci. 2007;28 Suppl 2:S97-S100.
Aguggia, M., D'Andrea, G., & Bussone, G. (2007). Neurophysiology and neuromodulators. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 28 Suppl 2, pp. S97-S100.
Aguggia M, D'Andrea G, Bussone G. Neurophysiology and Neuromodulators. Neurol Sci. 2007;28 Suppl 2:S97-S100. PubMed PMID: 17508189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurophysiology and neuromodulators. AU - Aguggia,M, AU - D'Andrea,G, AU - Bussone,G, PY - 2007/5/18/pubmed PY - 2007/8/11/medline PY - 2007/5/18/entrez SP - S97 EP - S100 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 28 Suppl 2 N2 - Migraine is an episodic brain disorder that results in significant morbidity. Antiepileptic drugs (neuromodulators) are increasingly recommended for migraine prevention because of placebo-controlled double-blind trials that prove them effective. Cortical spreading depression (CSD) is thought to be the pathophysiological correlate of the neurological symptoms in migraine with aura and neuromodulators may act on mechanisms involved in the initiation of CSD itself. Inhibition of trigeminocervical complex directly, or neurons that modulate sensory input, are also plausible mechanisms for the actions of neuromodulators in preventive therapy in migraine. Although it is unlikely that a single phenomenon serves as the only link between migraine and epilepsy, the neuronal hyperexcitability that may contribute to each condition may explain the effect of these drugs for both conditions. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/17508189/Neurophysiology_and_neuromodulators_ L2 - https://dx.doi.org/10.1007/s10072-007-0759-3 DB - PRIME DP - Unbound Medicine ER -