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Does naltrexone affect craving in abstinent opioid-dependent patients?
Addict Biol. 2007 Jun; 12(2):176-82.AB

Abstract

Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present study was to examine the effect of the administration of naltrexone on craving level after rapid opioid detoxification induced by naltrexone. A naturalistic study was carried out in which patients were followed during 10 months after rapid detoxification. Data about abstinence, relapse, and naltrexone use were collected by means of urine specimens. Craving was measured by the visual analogue scale craving, the Obsessive Compulsive Drug Use Scale, and the Desires for Drug Questionnaire. Results showed that patients who relapsed in opioid use experienced obviously more craving than abstinent people. Patients who took naltrexone did not experience significant less craving than those who did not. These results suggest that the use of opioids is associated with increased craving and that abstinence for opioids is associated with less craving, independent of the use of naltrexone. This is in contrast to the general opinion. Because of the naturalistic design of the study, no firm conclusions can be drawn, but the results grounded the needs of an experimental study.

Authors+Show Affiliations

Novadic-Kentron, Network for Addiction Treatment Services, Sint-Oedenrode, The Netherlands. boukje.dijkstra@novadic-kentron.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17508990

Citation

Dijkstra, Boukje A G., et al. "Does Naltrexone Affect Craving in Abstinent Opioid-dependent Patients?" Addiction Biology, vol. 12, no. 2, 2007, pp. 176-82.
Dijkstra BA, De Jong CA, Bluschke SM, et al. Does naltrexone affect craving in abstinent opioid-dependent patients? Addict Biol. 2007;12(2):176-82.
Dijkstra, B. A., De Jong, C. A., Bluschke, S. M., Krabbe, P. F., & van der Staak, C. P. (2007). Does naltrexone affect craving in abstinent opioid-dependent patients? Addiction Biology, 12(2), 176-82.
Dijkstra BA, et al. Does Naltrexone Affect Craving in Abstinent Opioid-dependent Patients. Addict Biol. 2007;12(2):176-82. PubMed PMID: 17508990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does naltrexone affect craving in abstinent opioid-dependent patients? AU - Dijkstra,Boukje A G, AU - De Jong,Cor A J, AU - Bluschke,Sarah M, AU - Krabbe,Paul F M, AU - van der Staak,Cees P F, PY - 2007/5/19/pubmed PY - 2007/8/19/medline PY - 2007/5/19/entrez SP - 176 EP - 82 JF - Addiction biology JO - Addict Biol VL - 12 IS - 2 N2 - Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present study was to examine the effect of the administration of naltrexone on craving level after rapid opioid detoxification induced by naltrexone. A naturalistic study was carried out in which patients were followed during 10 months after rapid detoxification. Data about abstinence, relapse, and naltrexone use were collected by means of urine specimens. Craving was measured by the visual analogue scale craving, the Obsessive Compulsive Drug Use Scale, and the Desires for Drug Questionnaire. Results showed that patients who relapsed in opioid use experienced obviously more craving than abstinent people. Patients who took naltrexone did not experience significant less craving than those who did not. These results suggest that the use of opioids is associated with increased craving and that abstinence for opioids is associated with less craving, independent of the use of naltrexone. This is in contrast to the general opinion. Because of the naturalistic design of the study, no firm conclusions can be drawn, but the results grounded the needs of an experimental study. SN - 1355-6215 UR - https://www.unboundmedicine.com/medline/citation/17508990/Does_naltrexone_affect_craving_in_abstinent_opioid_dependent_patients L2 - https://doi.org/10.1111/j.1369-1600.2007.00067.x DB - PRIME DP - Unbound Medicine ER -