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Vagus nerve stimulation therapy induces changes in heart rate of children during sleep.
Epilepsia. 2007 May; 48(5):923-30.E

Abstract

PURPOSE

This study analyzed changes in the heart rates of children receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy.

METHODS

Changes in the heart rates of ten children receiving VNS therapy for pharmacoresistant epilepsy were evaluated with polysomnographic recordings, including electrocardiogram (ECG), EEG, thoraco-abdominal distension, nasal airflow, and VNS artifacts. Measurements during stimulation were compared with those at baseline for each patient.

RESULT

While the VNS therapy pulse generator was delivering stimulation, the heart rates of four children increased significantly (p < 0.01), decreased for one child, and increased at the end of the stimulation for one child. The heart rates of four children did not change. Changes in heart rate varied during VNS, within stimulation cycles for individual children and from one child to another. Changes in heart rate differed between rapid eye movement (REM) and non-REM (NREM) sleep states. Respiratory changes (increases in frequency and decreases in amplitude) were concomitant with the changes in heart rate.

CONCLUSION

In this case series of children with pharmacoresistant epilepsy, cardiorespiratory variations occurred while the VNS therapy pulse generator was delivering stimulation. Understanding these variations may allow further optimization of VNS parameters.

Authors+Show Affiliations

GRAMFC, Faculté de Médecine, Amiens, France. boubker.zaaimi@u-picardie.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17509001

Citation

Zaaimi, Boubker, et al. "Vagus Nerve Stimulation Therapy Induces Changes in Heart Rate of Children During Sleep." Epilepsia, vol. 48, no. 5, 2007, pp. 923-30.
Zaaimi B, Grebe R, Berquin P, et al. Vagus nerve stimulation therapy induces changes in heart rate of children during sleep. Epilepsia. 2007;48(5):923-30.
Zaaimi, B., Grebe, R., Berquin, P., & Wallois, F. (2007). Vagus nerve stimulation therapy induces changes in heart rate of children during sleep. Epilepsia, 48(5), 923-30.
Zaaimi B, et al. Vagus Nerve Stimulation Therapy Induces Changes in Heart Rate of Children During Sleep. Epilepsia. 2007;48(5):923-30. PubMed PMID: 17509001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vagus nerve stimulation therapy induces changes in heart rate of children during sleep. AU - Zaaimi,Boubker, AU - Grebe,Reinhard, AU - Berquin,Patrick, AU - Wallois,Fabrice, PY - 2007/5/19/pubmed PY - 2007/7/19/medline PY - 2007/5/19/entrez SP - 923 EP - 30 JF - Epilepsia JO - Epilepsia VL - 48 IS - 5 N2 - PURPOSE: This study analyzed changes in the heart rates of children receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy. METHODS: Changes in the heart rates of ten children receiving VNS therapy for pharmacoresistant epilepsy were evaluated with polysomnographic recordings, including electrocardiogram (ECG), EEG, thoraco-abdominal distension, nasal airflow, and VNS artifacts. Measurements during stimulation were compared with those at baseline for each patient. RESULT: While the VNS therapy pulse generator was delivering stimulation, the heart rates of four children increased significantly (p < 0.01), decreased for one child, and increased at the end of the stimulation for one child. The heart rates of four children did not change. Changes in heart rate varied during VNS, within stimulation cycles for individual children and from one child to another. Changes in heart rate differed between rapid eye movement (REM) and non-REM (NREM) sleep states. Respiratory changes (increases in frequency and decreases in amplitude) were concomitant with the changes in heart rate. CONCLUSION: In this case series of children with pharmacoresistant epilepsy, cardiorespiratory variations occurred while the VNS therapy pulse generator was delivering stimulation. Understanding these variations may allow further optimization of VNS parameters. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/17509001/Vagus_nerve_stimulation_therapy_induces_changes_in_heart_rate_of_children_during_sleep_ DB - PRIME DP - Unbound Medicine ER -