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Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity.
Clin Exp Dermatol. 2007 Sep; 32(5):568-70.CE

Abstract

Interleukin (IL)-18 is a pleiotropic cytokine, which may play a role in autoimmune and allergic disorders. Serum IL-18 levels were measured in 34 patients with chronic ordinary urticaria (COU) and 17 normal subjects. In vivo and in vitro assays for histamine-releasing factors, an autologous serum skin test (ASST) and a basophil histamine release assay were also performed for all patients with COU. Serum IL-18 concentration was not significantly different between patients with COU and normal subjects (mean+/-standard error of the mean 246.47+/-18.40 pg/mL vs. 213.88+/-22.24 pg/mL), and no significant difference was found between ASST-positive and ASST-negative patients. However, in ASST-positive patients, IL-18 levels paralleled clinical severity scores and showed a tendency to correlate with in vitro histamine release. The increased IL-18 levels in the ASST-positive patients with most active chronic urticaria may reflect stronger immune system activation and possibly an involvement of IL-18 as a direct histamine-releasing factor.

Authors+Show Affiliations

Tedeschi A
Allergy and Clinical Immunology Unit, Hospital Maggiore Policlinico, Mangiagalli and Regina Elena, Fondazione IRCCS, Milan, Italy. albited@alice.it
Lorini M
No affiliation info available
Suli C
No affiliation info available
Asero R
No affiliation info available

MeSH

AdultBiomarkersCase-Control StudiesChronic DiseaseFemaleHumansInterleukin-18MaleMiddle AgedSkin TestsUrticaria

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17509061

Citation

Tedeschi, A, et al. "Serum Interleukin-18 in Patients With Chronic Ordinary Urticaria: Association With Disease Activity." Clinical and Experimental Dermatology, vol. 32, no. 5, 2007, pp. 568-70.
Tedeschi A, Lorini M, Suli C, et al. Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity. Clin Exp Dermatol. 2007;32(5):568-70.
Tedeschi, A., Lorini, M., Suli, C., & Asero, R. (2007). Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity. Clinical and Experimental Dermatology, 32(5), 568-70.
Tedeschi A, et al. Serum Interleukin-18 in Patients With Chronic Ordinary Urticaria: Association With Disease Activity. Clin Exp Dermatol. 2007;32(5):568-70. PubMed PMID: 17509061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity. AU - Tedeschi,A, AU - Lorini,M, AU - Suli,C, AU - Asero,R, Y1 - 2007/05/16/ PY - 2007/5/19/pubmed PY - 2008/2/26/medline PY - 2007/5/19/entrez SP - 568 EP - 70 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 32 IS - 5 N2 - Interleukin (IL)-18 is a pleiotropic cytokine, which may play a role in autoimmune and allergic disorders. Serum IL-18 levels were measured in 34 patients with chronic ordinary urticaria (COU) and 17 normal subjects. In vivo and in vitro assays for histamine-releasing factors, an autologous serum skin test (ASST) and a basophil histamine release assay were also performed for all patients with COU. Serum IL-18 concentration was not significantly different between patients with COU and normal subjects (mean+/-standard error of the mean 246.47+/-18.40 pg/mL vs. 213.88+/-22.24 pg/mL), and no significant difference was found between ASST-positive and ASST-negative patients. However, in ASST-positive patients, IL-18 levels paralleled clinical severity scores and showed a tendency to correlate with in vitro histamine release. The increased IL-18 levels in the ASST-positive patients with most active chronic urticaria may reflect stronger immune system activation and possibly an involvement of IL-18 as a direct histamine-releasing factor. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17509061/Serum_interleukin_18_in_patients_with_chronic_ordinary_urticaria:_association_with_disease_activity_ DB - PRIME DP - Unbound Medicine ER -