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A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases.
Aliment Pharmacol Ther 2007; 25(11):1317-27AP

Abstract

BACKGROUND

It has been suggested that coeliac disease (CD) is associated with several neurological diseases. However, the evidence of such an association is inconclusive as earlier research has often been based on small numbers with retrospective data collection.

AIM

To use Cox regression to examine the risk of neurological disease in individuals with CD.

METHODS

Through Swedish national registers we identified some 14 000 individuals with a diagnosis of CD (1964-2003) and 70 000 reference individuals matched for age, sex, calendar year and county.

RESULTS

Coeliac disease was associated with later polyneuropathy [hazard ratio (HR) = 3.4; 95% CI = 2.3-5.1]. We found no statistically significant association between CD and subsequent multiple sclerosis (HR = 0.9; 95% CI = 0.3-2.3), Parkinson's disease (HR = 1.2; 95% CI = 0.8-1.9), Alzheimer's disease (HR = 1.5; 95% CI = 0.9-2.6), hereditary ataxia (HR = 1.3; 95% CI = 0.5-3.6), the symptom ataxia (HR = 1.9; 95% CI = 0.6-6.2), Huntington's disease (HR = 1.7; 95% CI = 0.3-8.6), myasthenia gravis (HR = 0.8; 95% CI = 0.2-3.8) or spinal muscular atrophy (HR = 0.5; 95% CI = 0.1-3.8). Prior polyneuropathy was associated with subsequent CD (odds ratio = 5.4; 95% CI = 3.6-8.2).

CONCLUSIONS

The association between CD and polyneuropathy indicates shared risks. We suggest that individuals with polyneuropathy routinely undergo screening for CD. There is no notable association between CD and other neurological outcomes investigated in this study.

Authors+Show Affiliations

Department of Paediatrics, Orebro University Hospital, 70185 Orebro, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17509100

Citation

Ludvigsson, J F., et al. "A Population-based Study of Coeliac Disease, Neurodegenerative and Neuroinflammatory Diseases." Alimentary Pharmacology & Therapeutics, vol. 25, no. 11, 2007, pp. 1317-27.
Ludvigsson JF, Olsson T, Ekbom A, et al. A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases. Aliment Pharmacol Ther. 2007;25(11):1317-27.
Ludvigsson, J. F., Olsson, T., Ekbom, A., & Montgomery, S. M. (2007). A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases. Alimentary Pharmacology & Therapeutics, 25(11), pp. 1317-27.
Ludvigsson JF, et al. A Population-based Study of Coeliac Disease, Neurodegenerative and Neuroinflammatory Diseases. Aliment Pharmacol Ther. 2007 Jun 1;25(11):1317-27. PubMed PMID: 17509100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases. AU - Ludvigsson,J F, AU - Olsson,T, AU - Ekbom,A, AU - Montgomery,S M, PY - 2007/5/19/pubmed PY - 2007/12/13/medline PY - 2007/5/19/entrez SP - 1317 EP - 27 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 25 IS - 11 N2 - BACKGROUND: It has been suggested that coeliac disease (CD) is associated with several neurological diseases. However, the evidence of such an association is inconclusive as earlier research has often been based on small numbers with retrospective data collection. AIM: To use Cox regression to examine the risk of neurological disease in individuals with CD. METHODS: Through Swedish national registers we identified some 14 000 individuals with a diagnosis of CD (1964-2003) and 70 000 reference individuals matched for age, sex, calendar year and county. RESULTS: Coeliac disease was associated with later polyneuropathy [hazard ratio (HR) = 3.4; 95% CI = 2.3-5.1]. We found no statistically significant association between CD and subsequent multiple sclerosis (HR = 0.9; 95% CI = 0.3-2.3), Parkinson's disease (HR = 1.2; 95% CI = 0.8-1.9), Alzheimer's disease (HR = 1.5; 95% CI = 0.9-2.6), hereditary ataxia (HR = 1.3; 95% CI = 0.5-3.6), the symptom ataxia (HR = 1.9; 95% CI = 0.6-6.2), Huntington's disease (HR = 1.7; 95% CI = 0.3-8.6), myasthenia gravis (HR = 0.8; 95% CI = 0.2-3.8) or spinal muscular atrophy (HR = 0.5; 95% CI = 0.1-3.8). Prior polyneuropathy was associated with subsequent CD (odds ratio = 5.4; 95% CI = 3.6-8.2). CONCLUSIONS: The association between CD and polyneuropathy indicates shared risks. We suggest that individuals with polyneuropathy routinely undergo screening for CD. There is no notable association between CD and other neurological outcomes investigated in this study. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/17509100/A_population_based_study_of_coeliac_disease_neurodegenerative_and_neuroinflammatory_diseases_ L2 - https://doi.org/10.1111/j.1365-2036.2007.03329.x DB - PRIME DP - Unbound Medicine ER -