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Short-term effects of desmopressin on water and electrolyte excretion in adults with nocturnal polyuria.
J Urol. 2007 Jun; 177(6):2227-9; discussion 2230.JU

Abstract

PURPOSE

Increased calcium excretion due to desmopressin has been reported in children with nocturnal enuresis. Desmopressin is often used to treat adult patients with nocturnal polyuria. However, data on the effect of desmopressin on water/electrolyte excretion in adults are scarce. We present the short-term effects of desmopressin on water and electrolyte excretion in adult patients with nocturnal polyuria.

MATERIALS AND METHODS

A total of 16 male patients with nocturnal polyuria, mean age 76.3 years, received 0.1 or 0.2 mg desmopressin before sleep. Frequency volume chart was recorded, and daytime and nighttime urine samples were collected separately before and after desmopressin administration. Urinary excretions of sodium, potassium and calcium were determined, and compared before and after treatment with desmopressin.

RESULTS

Desmopressin significantly increased urine osmolality, decreased nocturnal total urine volume, reduced the ratio of nocturnal urine volume-to-whole day urine volume and decreased nocturnal voiding frequency. Nocturnal urinary excretion of calcium (mean 0.137 vs 0.169 mg/kg body weight per hour, p = 0.004) and whole day excretion of calcium (mean 165.9 vs 200.0 mg per day, p = 0.012) were increased after desmopressin treatment. Nocturnal urinary potassium excretion (mean 0.030 vs 0.025 mEq/kg body weight per hour, p = 0.030) and whole day potassium excretion (mean 40.7 vs 36.1 mEq per day, p = 0.017) were decreased by desmopressin treatment. However, desmopressin treatment did not significantly change urinary secretion of sodium and chloride at nighttime or for the whole day.

CONCLUSIONS

Desmopressin reduces nocturnal urine volume and nocturnal voiding frequency in male patients with nocturnal polyuria. However, increased calcium and decreased potassium excretion following desmopressin treatment deserve attention particularly when it is used on a long-term basis.

Authors+Show Affiliations

Division of Urology, Department of Surgery, Taipei Veterans General Hospital and Department of Urology, National Yang-Ming University, School of Medicine, No. 201 Sec. 2 Shih-Pai Road, Taipei, Taiwan 11217.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17509326

Citation

Chang, Yu-Lung, et al. "Short-term Effects of Desmopressin On Water and Electrolyte Excretion in Adults With Nocturnal Polyuria." The Journal of Urology, vol. 177, no. 6, 2007, pp. 2227-9; discussion 2230.
Chang YL, Lin AT, Chen KK. Short-term effects of desmopressin on water and electrolyte excretion in adults with nocturnal polyuria. J Urol. 2007;177(6):2227-9; discussion 2230.
Chang, Y. L., Lin, A. T., & Chen, K. K. (2007). Short-term effects of desmopressin on water and electrolyte excretion in adults with nocturnal polyuria. The Journal of Urology, 177(6), 2227-9; discussion 2230.
Chang YL, Lin AT, Chen KK. Short-term Effects of Desmopressin On Water and Electrolyte Excretion in Adults With Nocturnal Polyuria. J Urol. 2007;177(6):2227-9; discussion 2230. PubMed PMID: 17509326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of desmopressin on water and electrolyte excretion in adults with nocturnal polyuria. AU - Chang,Yu-Lung, AU - Lin,Alex T L, AU - Chen,Kuang-Kuo, PY - 2006/11/16/received PY - 2007/5/19/pubmed PY - 2007/7/18/medline PY - 2007/5/19/entrez SP - 2227-9; discussion 2230 JF - The Journal of urology JO - J Urol VL - 177 IS - 6 N2 - PURPOSE: Increased calcium excretion due to desmopressin has been reported in children with nocturnal enuresis. Desmopressin is often used to treat adult patients with nocturnal polyuria. However, data on the effect of desmopressin on water/electrolyte excretion in adults are scarce. We present the short-term effects of desmopressin on water and electrolyte excretion in adult patients with nocturnal polyuria. MATERIALS AND METHODS: A total of 16 male patients with nocturnal polyuria, mean age 76.3 years, received 0.1 or 0.2 mg desmopressin before sleep. Frequency volume chart was recorded, and daytime and nighttime urine samples were collected separately before and after desmopressin administration. Urinary excretions of sodium, potassium and calcium were determined, and compared before and after treatment with desmopressin. RESULTS: Desmopressin significantly increased urine osmolality, decreased nocturnal total urine volume, reduced the ratio of nocturnal urine volume-to-whole day urine volume and decreased nocturnal voiding frequency. Nocturnal urinary excretion of calcium (mean 0.137 vs 0.169 mg/kg body weight per hour, p = 0.004) and whole day excretion of calcium (mean 165.9 vs 200.0 mg per day, p = 0.012) were increased after desmopressin treatment. Nocturnal urinary potassium excretion (mean 0.030 vs 0.025 mEq/kg body weight per hour, p = 0.030) and whole day potassium excretion (mean 40.7 vs 36.1 mEq per day, p = 0.017) were decreased by desmopressin treatment. However, desmopressin treatment did not significantly change urinary secretion of sodium and chloride at nighttime or for the whole day. CONCLUSIONS: Desmopressin reduces nocturnal urine volume and nocturnal voiding frequency in male patients with nocturnal polyuria. However, increased calcium and decreased potassium excretion following desmopressin treatment deserve attention particularly when it is used on a long-term basis. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17509326/Short_term_effects_of_desmopressin_on_water_and_electrolyte_excretion_in_adults_with_nocturnal_polyuria_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.01.145?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -