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Pathogenic and molecular characterization of the H5N1 avian influenza virus isolated from the first human case in Zhejiang province, China.
Diagn Microbiol Infect Dis 2007; 58(4):399-405DM

Abstract

Since the reemergence of highly pathogenic avian influenza virus H5N1, it caused disease in 20 people with 13 deaths in mainland of China. On February 21, 2006, the first suspected human case in Zhejiang province was reported. Pathogenic analyses, including reverse transcriptase polymerase chain reaction (RT-PCR), real-time RT-PCR, and virus isolation, were carried out to confirm the pathogen from tracheal aspirate specimen. In addition, antibody in serum sample was detected using hemagglutination-inhibition (HI). Results revealed that nucleic acid extracted from the tracheal aspirate specimen was positive for H5N1 avian influenza virus and influenza virus type A. The H5N1 virus strain named A/Zhejiang/16/06 (H5N1) was isolated. The titers of HI antibody for H5N1 avian influenza virus were 1:320 and 1:640, respectively. The sequenced genes were all avian origin. Phylogenetic analyses between the A/Zhejiang/16/06 and other H5N1 influenza viruses were also included.

Authors+Show Affiliations

Institute of Virology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, China. jyyan@cdc.zj.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17509792

Citation

Yan, Juying, et al. "Pathogenic and Molecular Characterization of the H5N1 Avian Influenza Virus Isolated From the First Human Case in Zhejiang Province, China." Diagnostic Microbiology and Infectious Disease, vol. 58, no. 4, 2007, pp. 399-405.
Yan J, Lu Y, Mao H, et al. Pathogenic and molecular characterization of the H5N1 avian influenza virus isolated from the first human case in Zhejiang province, China. Diagn Microbiol Infect Dis. 2007;58(4):399-405.
Yan, J., Lu, Y., Mao, H., Feng, Y., Xu, C., Shi, W., ... Chen, Y. (2007). Pathogenic and molecular characterization of the H5N1 avian influenza virus isolated from the first human case in Zhejiang province, China. Diagnostic Microbiology and Infectious Disease, 58(4), pp. 399-405.
Yan J, et al. Pathogenic and Molecular Characterization of the H5N1 Avian Influenza Virus Isolated From the First Human Case in Zhejiang Province, China. Diagn Microbiol Infect Dis. 2007;58(4):399-405. PubMed PMID: 17509792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenic and molecular characterization of the H5N1 avian influenza virus isolated from the first human case in Zhejiang province, China. AU - Yan,Juying, AU - Lu,Yiyu, AU - Mao,Haiyan, AU - Feng,Yan, AU - Xu,Changping, AU - Shi,Wen, AU - Weng,Jingqing, AU - Li,Minhong, AU - Gong,Liming, AU - Ge,Qiong, AU - Zhou,Min, AU - Li,Zhen, AU - Chen,Yin, Y1 - 2007/05/16/ PY - 2006/08/30/received PY - 2007/02/28/revised PY - 2007/03/04/accepted PY - 2007/5/19/pubmed PY - 2007/10/24/medline PY - 2007/5/19/entrez SP - 399 EP - 405 JF - Diagnostic microbiology and infectious disease JO - Diagn. Microbiol. Infect. Dis. VL - 58 IS - 4 N2 - Since the reemergence of highly pathogenic avian influenza virus H5N1, it caused disease in 20 people with 13 deaths in mainland of China. On February 21, 2006, the first suspected human case in Zhejiang province was reported. Pathogenic analyses, including reverse transcriptase polymerase chain reaction (RT-PCR), real-time RT-PCR, and virus isolation, were carried out to confirm the pathogen from tracheal aspirate specimen. In addition, antibody in serum sample was detected using hemagglutination-inhibition (HI). Results revealed that nucleic acid extracted from the tracheal aspirate specimen was positive for H5N1 avian influenza virus and influenza virus type A. The H5N1 virus strain named A/Zhejiang/16/06 (H5N1) was isolated. The titers of HI antibody for H5N1 avian influenza virus were 1:320 and 1:640, respectively. The sequenced genes were all avian origin. Phylogenetic analyses between the A/Zhejiang/16/06 and other H5N1 influenza viruses were also included. SN - 0732-8893 UR - https://www.unboundmedicine.com/medline/citation/17509792/Pathogenic_and_molecular_characterization_of_the_H5N1_avian_influenza_virus_isolated_from_the_first_human_case_in_Zhejiang_province_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(07)00111-3 DB - PRIME DP - Unbound Medicine ER -